Preliminary Clinical Study of the Presence of Trichomonas Tenax and Entamoeba Gingivalis in Patients With Periodontitis Consulting to CHU of Nancy, in Periodontal Department.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 主要终点
- Presence of protozoans
研究概览
简要总结
The buccal cavity presents microorganismes whose the number and composition vary with oral hygiene and medical context (pathologies and associated drug therapies) of the patient. More than 1200 bacterial species have been identified, and among them, 400 are inhabitants of the sub-gingival biofilm. Among all these microorganismes, only 20 species participate to the etiopathogenesis of periodontal diseases.Some are recognised as major periodontopathogens other play unclear role in this pathology. They belong respectively to the red and orange complex of Socransky et al. (1998).
Other microorganismes such as virures, yeasts and protozoans could potentially impact the emergence and development of periodontal diseases. The presence of protozoans in periodontitis have been investigated in this study.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults > 18 years-old
- •Consulting in periodontal department of CHU, Nancy
- •Patient with moderate to severe periodontitis
- •At least 2 periodontal sites with PPD≥ 4mm and One healthy site
- •No scaling root planning in the last 6 months
- •Patients insured under the French social security system
排除标准
- •Pregnant patients
- •Patients with antibiotic therapy, and/or all medecines which could modify the buccal microbiota in the last 6 months
- •Tooth with endodontic periapical lesion
- •Patients having a scaling root planning in the last 6 months
- •Patient with guardianship
结局指标
主要结局
Presence of protozoans
时间窗: baseline
次要结局
- Clinical attachment loss (mm)(baseline)
- Periodontal pocket depth (mm)(baseline)
- Plaque and gingival index(baseline)
- Presence of bleeding on probing (Yes/No)(baseline)
- Mobility of the tooth (Yes/No)(baseline)