Resolution of delayed gastric emptying, reduced glucose absorption and hypercatabolism in survivors of critical illness

Dr Lee-anne Chapple0 个研究点目标入组 40 人开始时间: 2018年3月12日最近更新: 2024年2月27日

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•Critically ill patients:
•Patients admitted to the Royal Adelaide Hospital Intensive Care Unit (ICU) from March 2018 will be assessed for eligibility. Thirty eligible patients will be recruited (accounting for drop-outs to reach the target of 20 patients).
•- Aged greater than or equal to 18 years of age
•- Receiving invasive mechanical ventilation
•- Planned to receive enteral nutrition
•- Patients expected to remain ventilated for greater than 48 hours and stay in ICU for greater than 72 hours
•- Feed intolerant (defined as at least one gastric residual volume of greater than or equal to 250 mL in the 24 hrs preceding enrolment, or if gastrokinetic drugs were already prescribed to the patient on the basis of gastric residual volume of greater than or equal to 250 mL)
•Healthy participants:
•Data will be compared with that from 10 age, sex, and BMI-matched healthy participants. Healthy participants will be recruited by advertisement within the Royal Adelaide Hospital.

•Critically ill patients:
•- Patients expected to be unable to follow commands and give informed consent after extubation (i.e. head injured, subarachnoid haemorrhage and history of dementia)
•- Gastrointestinal surgery on this admission
•- Previous upper gastrointestinal surgery (oesophageal, stomach or duodenal)
•- Unable to obtain informed consent
•- Lives greater than 50km from Adelaide (therefore unable to return for 3 month study day)
•- Patient’s next of kin believe the patient will not be willing to have study measurements completed on hospital ward after ICU discharge and also return to the hospital for follow up at 3 months.
•- Likely not survive ICU
•- Haemoglobin <80g/L
•Healthy participants:
•- Inability to give informed consent
•- Pregnant or breastfeeding
•- Previous gestational diabetes
•- Acute or chronic pancreatitis
•- Medications known to affect glucose metabolism (e.g. steroids) or gastrointestinal motility (e.g. prokinetics, antidepressants, sedatives, opiates, anticonvulsant agents)
•- Previous gastrointestinal surgery (apart from appendectomy)
•- Current or previous gastrointestinal disease or major dysfunction
•- Regular consumption >20 g alcohol or >10 cigarettes per day

发起方

Dr Lee-anne Chapple