The Role of Pyroptosis and Ferroptosis in the Pathophysiology of Lymphedema
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- The correlation between post-LVA volume reduction
研究概览
简要总结
The project aims to compare the differences in the expression of cell death through apoptosis and iron-dependent cell death after the reduction of edema symptoms following lymphedema surgery in patients.
详细描述
This project aims to investigate the expression of cell death through apoptosis and iron-dependent cell death in the subcutaneous adipose tissue of patients with lymphedema. The study also seeks to explore the roles of these processes among lymphatic endothelial cells, adipocytes, and macrophages, and their association with lymphedema, thus gaining insights into the pathophysiological mechanisms of lymphedema. Furthermore, the project aims to compare the differences in the expression of cell death through apoptosis and iron-dependent cell death after the reduction of edema symptoms following lymphedema surgery in patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Control Group: Patients who have not experienced lymphedema but require surgery due to other diseases such as cancer, trauma, chronic wounds, skin defects, etc.
- •Experimental Group: Patients who have lymphedema and undergone lymphedema surgery.
排除标准
- •Individuals with venous thrombosis, chronic heart failure, and renal failure.
- •Vulnerable populations, individuals with limited mobility, pregnant women, and minors.
- •Those expected to be unable to attend follow-up visits or complete the study smoothly.
- •Participants who express doubts about the trial and cannot provide satisfactory answers.
结局指标
主要结局
The correlation between post-LVA volume reduction
时间窗: 1 month after surgery
The differences in expression of cell necrosis and iron-dependent cell death after lymphedema surgery were observed in patients, following alleviation of edema symptoms.
次要结局
未报告次要终点