COMPARISON OF THE EFFECT OF PERIOPERATIVE INTRAVENOUS INFUSION OF DEXMEDETOMIDINE AND LIGNOCAINE VERSUS FENTANYL ON INTRAOPERATIVE HAEMODYNAMICS AND POSTOPERATIVE ANALGESIA IN ELECTIVE LAPAROSCOPIC SURGERY
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 200
- 试验地点
- 1
研究概览
简要总结
Laparoscopic surgeries are becoming popular due to several postoperative benefits allowing quicker recovery, less tissue damage, avoiding big surgical incision, shorter hospital stay with consequent reduction in health care cost. But anaesthetic management in these patients has become complicated due to cardiopulmonary changes occurring during creation of pneumoperitoneum with CO2 and patient position required for different laparoscopic surgeries.
Laryngoscopy, tracheal intubation and pneumoperitoneum are associated with sympathetically mediated adverse haemodynamic effect like elevation of arterial pressure, heart rate and decrease in cardiac output which adversely affect the outcome. Dexmedetomidine is selective alpha 2 adrenoceptor agonist. It has central sympatholytic action which helps in providing haemodynamic stability. It also has both analgesic and anaesthetic sparing property and Lignocaine is local anaesthetic has proven effect on attenuating stress response during intubation and extubation, also provides analgesia. Hence, this study was designed to evaluate the effect of Dexmedetomidine and Lignocaine in patient hemodynamics, postoperative analgesia in comparison to fentanyl during laparoscopic cholecystectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Double
入排标准
- 年龄范围
- 18.00 Day(s) 至 65.00 Day(s)（—）
- 性别
- All
入选标准
- •Adults age 18–65 years.
- •ASA physical status I–II (or III if you prefer).
- •Scheduled for elective laparoscopic procedures under general anesthesia with expected duration 60–180 minutes.
- •Able to provide informed consent.
排除标准
- •Known allergy to study drugs (dexmedetomidine, lignocaine, fentanyl).
- •Severe cardiac conduction disease (2nd or 3rd degree heart block without pacemaker).
- •Significant hepatic dysfunction, severe renal impairment.
- •Pregnancy or breastfeeding.
- •Chronic opioid use or chronic pain requiring opioids.
- •BMI more than 35 Severe psychiatric disease or inability to report pain scores.
- •Seizure disorder relative contraindication to lignocaine infusion.
研究者
Wg Cdr Dr Bhaskar Das
7 Air Force Hospital