Regulation of Incretin Release by Non-nutritive Sweeteners in Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 17
- 试验地点
- 2
- 主要终点
- The Effect of Sucralose on Insulin Concentration (Area Under the Curve; AUC)
研究概览
简要总结
Several sugar-replacement sweeteners are currently on the market, including saccharine (ex. Sweet'N Low), aspartame (ex. Equal), and sucralose (ex. Splenda). The purpose of this study is to examine wether non caloric sweeteners affects how well the body works to control blood sugar. The study includes detailed blood sugar testing after drinking liquids that may contain sucralose. The investigators hypothesize that drinking liquids with sucralose will effect the amounts of specific appetite-affecting substances naturally produced by the body.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •body mass index (BMI) over
- •Homeostasis model assessment of insulin resistance (HOMA-IR) < or = 2.6
排除标准
- •smoking or smoked within last six months
- •pregnant or breastfeeding
- •have malabsorptive syndromes
- •intestinal inflammatory disease
- •liver or kidney disease
- •fructose intolerance
- •consuming more than one can of diet beverage or one spoonful of non-nutritive sweeteners (e.g. sucralose, aspartame, or saccharine) a week.
- •taking any medication that might affect metabolism or taste.
结局指标
主要结局
The Effect of Sucralose on Insulin Concentration (Area Under the Curve; AUC)
时间窗: Baseline
we will measure plasma insulin concentrations during a 5-hour modified Oral Glucose Tolerance Test (mOGTT) administered 10 minutes after subjects consume sucralose in water or an equal volume of water without sucralose (control condition).Plasma insulin concentrations were measured at 20, 15, 10, 6, and 2 min before and at 10, 20, 30, 40, 60, 90, 120, 150,180, 240, and 300 min after ingesting 75g of glucose. All these data collected were used to create the AUC curve.
次要结局
未报告次要终点
研究者
Marta Yanina Pepino de Gruev
Research Assistant Professor of Medicine
Washington University School of Medicine