Effect of Platelet Rich Fibrin on Septoplasty :A Comparative Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 主要终点
- Effect of submucoperichondrial application of platelet rich fibrin on healing of nasal septum mucosa after septoplasty
研究概览
简要总结
The aim of this study is to assess the effectiveness of Platelet-Rich Fibrin (PRF) in improving postoperative healing, reducing complications, and enhancing functional outcomes in patients undergoing septoplasty
详细描述
Septoplasty is a routine surgical intervention to correct nasal septal deviation, a major cause of nasal obstruction and chronic sinusitis. Despite advancements, postoperative complications-such as mucosal injury, synechiae, septal perforation, and hematoma-continue to impact outcomes and patient satisfaction.
Platelet-rich fibrin (PRF), first described by Choukroun et al., represents an autologous biomaterial rich in growth factors like PDGF, TGF-β, VEGF, and IGF-1, known to accelerate wound healing and tissue regeneration. Unlike platelet-rich plasma (PRP), PRF is easier to prepare, does not require anticoagulants, and forms a fibrin matrix conducive to sustained release of cytokines.
Several studies across disciplines-oral surgery, dermatology, orthopedics-support the regenerative potential of PRF. In nasal surgery, the delicate mucosal environment could benefit significantly from enhanced healing facilitated by PRF.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- — 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults aged 18-65 years undergoing septoplasty. Presence of cartilage deviated nasal septum requiring repair. No contraindications to PRF therapy.
排除标准
- •History of coagulopathy or anticoagulant therapy. Active infection or systemic disease. Known hypersensitivity to PRF components. Previous nasal surgery Autoimmune or systemic inflammatory disease
研究组 & 干预措施
platelet rich fibrin
usage of platelet rich fibrin in this arm underging setoplasty
干预措施: Effect of Platelet Rich Fibrin on Septoplasty (Other)
control group
traditional septoplasty
干预措施: Effect of Platelet Rich Fibrin on Septoplasty (Other)
结局指标
主要结局
Effect of submucoperichondrial application of platelet rich fibrin on healing of nasal septum mucosa after septoplasty
时间窗: postoperative at 1st week , 1st month , 3rd month
Mucosal Healing will be assessed by visual nasal endscope
次要结局
未报告次要终点
研究者
Ahmed Ibrahim Abdallah Abdel wahd Abo Hussein
ahmed ibrahim
Kafrelsheikh University