Cognitive Processing Therapy Versus Sertraline for the Treatment of Post-traumatic Stress Disorder & Substance Use Disorder Egyptian Patients
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 150
- 主要终点
- Questionnaire
研究概览
简要总结
The present research was aimed at comparing the effects of Cognitive Processing Therapy (CPT) with the effects of Sertraline in treating patients who have dual diagnosis PTSD & SUD. The present study examines the extent to which CPT is effective in treating PTSD symptoms for patients with PTSD and SUD.
详细描述
Patients with co-occurrence PTSD & SUD disorders were grouped into 3 groups: first: Cognitive Processing Therapy (CPT) in which participants completed 12 sessions of CPT. Second: were treated by Sertraline. Third: a placebo control group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
盲法说明
This is a three-group, repeated-measure, parallel-group, Randomized Control Trial design. Patients, study psychiatrists, and assessors were blind to treatment condition assignment. Randomization blocks of three were used to maintain equal group size. The 3-month assessment serves as the post-treatment. Outcome assessments were PTSD severity, substance use severity, and depression. The pharmacy of Ain Shams Hospital created sertraline and matching placebo kits with single-identifier numbers based on a random code that was provided to an unblinded statistician who will instruct the psychiatrist how to distribute kits to patients.
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed with SUD
排除标准
- •Patients diagnosed with other psychotic disorders
研究组 & 干预措施
Cognitive processing therapy
Cognitive Processing Therapy (CPT) in which participants completed 12 sessions of CPT
干预措施: Cognitive processing therapy (Behavioral)
Sertraline
Patients with co-occurrence PTSD & SUD disorders were treated by Sertraline.
干预措施: Sertraline (Drug)
Control group
Placebo Control group
干预措施: Placebo Control (Other)
结局指标
主要结局
Questionnaire
时间窗: 3 Months
A psychological parameter will be measured to check the efficacy of CPT against medication for the treatment for co-current PTSD \& SUD. The groups will be examined to show if any significant reductions in PTSD and SUD symptoms was obtained over time.
次要结局
未报告次要终点
研究者
Amani Safwat Albrazi
Principal Investigator
British University In Egypt