Effects of Adapated Physical Activity Program on Kynurenin Metabolism During Refeeding in Anorexia Nervosa : APANOR Study
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- To evaluate the effects of adapated physical activity (APA) program on kynurenin metabolism
研究概览
简要总结
Physical hyperactivity is often associated to anorexia nervosa (AN). Data suggest common central pathways between hyperactivity and anorexia. Maintaining adapted physical activity (APA) during refeeding in AN is controversial. Many studies suggest beneficits of APA in AN on body composition (increase fat free mass and better distribution of fat mass), mood regulation, bone metabolism. We recently reported benefits of maintaining physical activity during refeeding in a mice model of anorexia (activity-based anorexia model). These benefits involved the tryptophan-kynurenin pathway. Thus, we aim in the APANOR study to assess effects of APA during refeeding in AN on kynurenin metabolism.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patient > 18 years
- •Follow-up in the department of clinical Nutrition of Rouen
- •BMI ≥15,0 and <18,5 kg/m²
- •Diagnosis of anorexia nervosa according to DSM-V classification
排除标准
- •Physical activity contraindications : hemodynamic disorder, uncontrolled cardiovascular disease, intracranial hypertension
- •Patients with poor understanding of spoken or written French
- •Person deprived of their liberty by an administrative or judicial decision or person subject to a legal measure for the protection of adults
- •Person subject to a safeguard of justice, guardianship or curatorship.
- •Pregnant or breastfeeding woman
研究组 & 干预措施
Without adapted physical activity program (APA)
干预措施: physical activity program (APA) (Other)
With adapted physical activity program (APA)
干预措施: physical activity program (APA) (Other)
结局指标
主要结局
To evaluate the effects of adapated physical activity (APA) program on kynurenin metabolism
时间窗: 3 months
Variation of plasmatic kynurenin acid between V1 and V2 in patients undergoing APA during refeeding versus other patients (control group without APA)
次要结局
- To evaluate the effects of adapated physical activity program on Body composition (fat mass, fat free mass)(3 months)
- To evaluate the involving of gut microbiota composition and diversity(3 months)
- To evaluate the involving of auto-antibodies against neuropeptides involved in food intake regulation(3 months)
- To evaluate the effects of adapated physical activity program on anthropometric data.(3 months)
- To evaluate the effects of adapated physical activity program on quality of life(3 months)