A transversal PET study using [11C]K-2 to investigate age-and-sex-related changes AMPA receptor density in healthy volunteers.

Abe Hiroki0 个研究点目标入组 100 人开始时间: 2020年8月12日最近更新: 2023年10月17日

适应症

试验速览

暂无简介。

•We will target healthy volunteers who meet all the following conditions.
•1.Males and females between 20 and 70 years old at the time of obtaining informed consent.
•2.No history of mental or neurological disease.
•3.Sufficient consent judgment ability of the person in the evaluation by MacCAT.
•4.No current mental disorders without meeting any criteria in SCID-I /DSM-IV,DSM-5, ICD-10.

•1. Person with psychotropic drugs, antidepressant, hypnotic, anxiolytic, antipsychotic.
•2. Pregnant, lactating female.
•3. Hypersensitive to ethanol.
•4. neurolog ical disease (neurodegenerative disease, minor cerebral hemorrhage or cerebral infarction)
•5. History of malignant brain tumor
•6. History of epilepsy
•7. Under medical treatment for other diseases
•8. Substance-related disorders within 6 months except for nicotine and caffeine
•9. Positive urine recreational drug screening (excluding person who takes the drugs for medication purposes)
•10. Pacemaker or any metal devices in the body
•11. Head, neck and body size are not suitable for MRI scanner
•12. Big tattoo and art makeup on their skin
•13. Severe claustrophobia
•14. Congenital or traumatic brain abnormalities
•15.Any of the following abnormal laboratory test values
•Serum creatinine 1.5mg / dl or more
•AST 150IU/L or more
•ALT 150IU/L or more
•16. Person who have taken [11C] K-2 PET in other clinical trials.
•17. Participants with unapproved nuclear medicine tests or clinical trials within 6 months before registration
•18. Participants of other clinical trials or clinical trials within 12 weeks prior to enrollment (limited to those with invasion/intervention)
•19. other reasons by the investigator

发起方

Abe Hiroki