Clinical Efficacy of 17% Hydrogen Peroxide alone or in Combination with Cobalt-Tetraphenylporphyrin Complex, Functionalized with Reduced Graphene Oxide for Bleaching in Adults with Moderate Fluorosis
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 入组人数
- 45
- 试验地点
- 1
研究概览
简要总结
This clinical study evaluates the effectiveness of a low-concentration bleaching agent—17 percent hydrogen peroxide—used alone and in combination with a cobalt-tetraphenylporphyrin (CoTPP) complex functionalized with reduced graphene oxide (RGO) for treating moderate dental fluorosis in adults. Fluorosis causes intrinsic enamel discoloration, and current high-concentration bleaching agents may induce sensitivity and enamel changes. The CoTPP/RGO nanocomposite acts as a catalyst to enhance peroxide activity while minimizing side effects. Forty-five patients will be divided into three groups and assessed for shade improvement, sensitivity, and satisfaction using VAS scales. The study aims to identify the most effective, safer bleaching approach.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients between age group of 18-40 years.
- •Patients with moderate fluorosis in anterior teeth – score 3, classified according to the Dean Fluorosis Index- Modified (1942).
- •Tooth should have enough tooth structure for rubber dam placement.
排除标准
- •Patient with history of allergy toward any dental material.
- •Patient with fractured maxillary central or lateral incisors.
- •Patients with Class V carious lesions, smoking habit, pregnant, or lactating woman.
研究者
Dr Vishakha GIrdhar
Shree Guru Govind Singh Tricentenary University