Perception in Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- Parkinson's Anxiety Scale (PAS)
研究概览
简要总结
The investigators plan to examine the relation of perceptual variables-basic vision, unusual perceptual experiences(including but not limited to visual hallucinations)-to relevant functional variables such as cognition, mood, and alertness/sleepiness in an online sample of persons with Parkinson's disease (PwPD). It is hypothesized that unusual perceptual experiences will relate significantly to the selected variables. Participants do not need to experience visual hallucinations to be able to participate in this study. This is an observational study only, and not an interventional study.
详细描述
For this study, the investigators propose to conduct an online study of PwPD (proposing a total of 60 participants) to examine the relations among variables that may relate to perception in PD. Those PwPD who express interest will be sent a link to an online survey (Qualtrics). The investigators will collect demographic and health information, followed by questionnaires assessing unusual perceptual experiences, mood, motivation, sleep, fatigue and quality of life. The survey should take roughly 45 minutes to an hour to complete.
Compensation: A $20 Amazon gift card will be offered to those who complete the survey all the way through with good effort.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 110 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participants must be at least 40 years old
- •Have a self-reported diagnosis of idiopathic PD
- •Be proficient English speakers
- •Have functional vision
- •Have internet access, and access to a desktop computer or laptop
排除标准
- •Self-reported poor vision (non-functional range)
- •Lack of access to internet and either a desktop computer or laptop
结局指标
主要结局
Parkinson's Anxiety Scale (PAS)
时间窗: Baseline
Assesses the severity of anxiety symptoms in persons with Parkinson's disease. Maximum score:48. Higher scores indicate more severe anxiety.
Penn Online Evaluation of Migraine (POEM)
时间窗: Baseline
Assesses headaches and migraine-related history.
Noise Pareidolia Test
时间窗: Baseline
Assesses tendency to see meaningful objects such as faces, animals, and objects in ambiguous patterns. Higher scores (on items with no face) indicate a higher number of pareidolic responses.
Center for Epidemiological Studies Depression Scale (CES-D)
时间窗: Baseline
Assesses depressive symptoms in the general population. Maximum score:60. Higher scores indicate more severe depression.
NIH NeuroQoL measures
时间窗: Baseline
Assesses health-related quality of life in adults with neurological disorders. Higher scores on the sub-scales indicate worse outcomes.
Mooney Faces
时间窗: Baseline
Assesses the ability to see an upright, inverted, or scrambled face in a black and white pattern. Higher scores (on items with no face) indicate a higher number of pareidolic responses.
BU Hallucinations and Unusual Perceptual Experiences questionnaire (BU-HUPE)
时间窗: Baseline
Assesses different types of visual hallucinations - simple VH; illusions; minor hallucinations: vivid sense of presence or movement in periphery (passage); and complex VH (e.g., people, animals, objects), as well as temporal and descriptive characteristics of the hallucinations. Higher scores indicate more unusual perceptual experiences.
Prodromal Questionnaire, Brief Version (PQ-B)
时间窗: Baseline
Assesses risk for psychosis by asking about positive symptoms and related distress/impairment. Higher scores indicate higher risk for psychosis and higher related distress.
Parkinson's Disease - Psychotic Symptoms Scale (PD-PSS)
时间窗: Baseline
Assesses the frequency and severity of minor hallucinations (passage hallucinations, presence hallucinations, visual illusions), and structured hallucinations in PD. Higher scores indicate higher frequency of psychotic symptoms.
Epworth Sleepiness Scale (ESS)
时间窗: Baseline
Assesses a person's general level of daytime sleepiness. Maximum Score: 24. Higher scores indicate a higher chance of dozing.
Parkinson's Disease Sleep Scale-2
时间窗: Baseline
Assesses sleep and nocturnal disturbances in Parkinson's disease. Maximum score: 60. Higher scores indicate more frequent sleep disturbances.
Parkinson's Disease Questionnaire - 39 (PDQ-39)
时间窗: Baseline
Assesses Parkinson's disease-specific health-related quality of life. Higher scores indicate worse quality of life.
Non-Motor Symptoms Questionnaire (NMSQ)
时间窗: Baseline
Assesses a range of non-motor symptoms in Parkinson's disease. Higher scores indicate the presence of more non-motor symptoms.
The Movement Disorders Society Unified Parkinson Disease Rating Scale (MDS-UPDRS)
时间窗: Baseline
Assesses motor and non-motor experiences of daily living in Parkinson's disease. Higher scores indicate increased severity of motor and non-motor symptoms.
次要结局
未报告次要终点
研究者
Alice Cronin-Golomb
Director, Vision and Cognition Laboratory
Boston University Charles River Campus