Health effects due to inhalation of ultrafine particles in healthy volunteers. Multiple short-term exposures to UFP near Schiphol Airport. A cross-over study - Health effects due to inhalation of ultrafine particles

RIVM0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年6月11日

适应症

试验速览

暂无简介。

•* Healthy subjects between 18 and 35 years of age
•* Baseline FEV1 > than 80% of predicted value
•* Able to communicate well with the investigator and to comply with the requirements of the study
•* Written informed consent
•* No current smoking for at least 1 year and less than 5 pack years of smoking history.

•* History of pulmonary or cardiovascular events/diseases
•* History of hay fever/pulmonary disease
•* Use of medications that affect pulmonary or cardiovascular parameters
•* History of enhanced bleeding tendency
•* A history of smoking within the last 12 months, or regular consumption of greater than three units of alcohol per day
•* Administration of any investigational drug within 30 days of study initiation
•* Current pregnancy
•* Donation of blood within 60 days, or loss of greater than 400 ml of blood within 12 weeks of study initiation
•* Respiratory tract infection in the last 6 weeks before or during the study
•* Use of alcohol, tobacco and caffeine-containing drinks in the 24 hours before measurement
•* History of serious drug-related reactions, including hypersensitivity
•* Residency or daily work/study activities within 100 meters of a busy road or 300 meters from a freeway.
•* Residency or daily work/study activities in the area of Schiphol Airport or within distance of 2 kilometres of the Schiphol area.

发起方

RIVM