NCT00985699已完成不适用
Pharmacogenomics of Oxidative Stress-Related Genes in Lymphoma
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 337
- 主要终点
- Association of polymorphisms in oxidative stress-related genes with overall survival and/or progression-free survival
研究概览
简要总结
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is looking at genes in tissue samples from patients with B-cell non-Hodgkin lymphoma.
详细描述
OBJECTIVES:
- To determine if toxicity following treatment for lymphoma varies according to genetic polymorphisms in oxidative stress-related genes (i.e., SOD2, CAT, GPX1, GSTM1, and GSTP1).
- To assess whether these genetic polymorphisms are associated with progression-free survival and/or overall survival in these patients treated for lymphoma.
OUTLINE: Previously collected samples are used for biomarker analysis.
研究设计
- 研究类型
- Observational
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Association of polymorphisms in oxidative stress-related genes with overall survival and/or progression-free survival
时间窗: retrospectively
Association of polymorphisms in these genes with rate of grade 4-5 hematologic toxicity
时间窗: retrospectively
次要结局
未报告次要终点
研究者
相似试验
已完成
不适用
SWOG 8897-A DNA Analysis in Predicting Treatment Outcome in Women With Breast Cancer in SWOG 8897Breast CancerNCT00896623SWOG Cancer Research Network1,577
已完成
不适用
Biomarker Study of Chemotherapy Resistance and Outcomes in Samples From Older Patients With Acute Myeloid LeukemiaLeukemiaNCT01421875Eastern Cooperative Oncology Group257
已完成
不适用
Biomarkers in Patients With Diffuse Large B-Cell Lymphoma Treated With Combination Chemotherapy With or Without RituximabLymphomaNCT01131208ECOG-ACRIN Cancer Research Group200
已完成
不适用
Identifying Risk Factors for Bone Tissue Death in Young Patients With Acute Lymphoblastic Leukemia Treated on Clinical Trial CCG-1882LeukemiaNCT00898469Children's Oncology Group671
已完成
不适用
Trastuzumab in Treating Women With Metastatic Breast CancerBreast CancerNCT00896376Centre Antoine Lacassagne49