Influence of Cognitive Load on Postural Control in People With Chronic Obstructive Pulmonary Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Difference of the range of COP displacement between groups and experimental conditions
研究概览
简要总结
Postural control impairment is common in people with COPD (pwCOPD), which can increase the risk of falls and affect quality of life. However, the majority of existing studies examine this postural control in isolation, without taking into account the cognitive demands that occur during activities of daily living during which individuals are often required to perform a mental task while maintaining their balance. This research aims to fill this gap by studying how a cognitive task can influence postural control in pwCOPD. We hypothesized an impaired postural control in pwCOPD compared to healthy individuals, which would be exacerbated in presence of a cognitive task.
详细描述
This observational study is based on the analyses of data (center of pressure displacement) recorded during the first visit of NEUROTIGUE study (NCT04028973).
Center of pressure (COP) displacement were recorded during 60s of static balance in four conditions (random order) :
- Eyes open without cognitive task
- Eyes open with cognitive task
- Eyes closed without cognitive task
- Eyes closed with cognitive task The cognitive task used was a working memory task : the 1-back task. COP displacement will be assess using a conjunction of parameters to provide a comprehensive understanding of postural control (e.g., amplitude, standard deviation, non-linear approaches).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •COPD patients :
- •GOLD II - III or IV
- •FEV1 <80% of predicted values
- •Men and women aged 40 years and over
- •French-speaking participant
- •BMI <30 kg / m²
- •Stable condition (i.e. without exacerbation) for more than 15 days
- •Able to express their consent in writing prior to any participation in the study
- •Affiliates or beneficiaries of a social security
- •Minimum score of 26 on the MMSE questionnaire of 3 months or less
- •Healthy volunteers :
- •Men and women aged 40 years and over
- •French-speaking participant
- •BMI <30 kg / m²
- •No known chronic respiratory, cardiovascular, metabolic, renal or neuromuscular pathologies
- •Able to express their consent in writing prior to any participation in the study
- •Affiliates or beneficiaries of a social security
- •Minimum score of 26 on the MMSE questionnaire of 3 months or less
- •For all participants :
- •Subject who has not objected to the reuse of data collected
排除标准
- •COPD patients :
- •Alcoholism, i.e. > 21 glasses a week for men and >14 glasses a week for women
- •Psychiatric pathologies or antecedent of behavioral disorders
- •Patients treated with oral or systemic corticosteroids (> 0.5 mg / kg / day for > 7 days)
- •Contraindication to the application of a magnetic field (i.e. right hip arthroplasty, pelvic / abdominal surgeries)
- •Severe vision or hearing problems not corrected
- •Patient oxygen dependent
- •Patients in exclusion period from another research protocol
- •Pregnant women (known pregnancy) or lactating women
- •Patient deprived of liberty by a judicial or administrative decision
- •Patient subject to a legal protection measure or unable to express their consent
- •Patient who is not sufficiently fluent in reading and understanding the French language to be able to consent to participate in the study
- •Patient unable to follow study procedures and to respect visits throughout the study period
- •Person with a medical history that, in the opinion of the investigator, could interfere with the results of the study
- •Any condition that, in the opinion of the investigator, could increase and compromise the safety of the person in the event that he / she participates in the study
- •Any other reason that, in the opinion of the investigator, could interfere with the evaluation of the aims of the study
- •Healthy volunteers:
- •Alcoholism, i.e. > 21 glasses a week for men and >14 glasses a week for women
- •Psychiatric pathologies or antecedent of behavioral disorders
- •Patients treated with oral or systemic corticosteroids (> 0.5 mg / kg / day for > 7 days)
- •Contraindication to the application of a magnetic field (i.e. right hip arthroplasty, pelvic / abdominal surgeries)
- •Severe vision or hearing problems not corrected
- •Subjects in exclusion period from another research protocol
- •Pregnant women (known pregnancy) or lactating women
- •Regular physical activity with a frequency greater than 3 sessions per week
- •Participant deprived of liberty by a judicial or administrative decision
- •Participant subject to a legal protection measure or unable to express their consent
- •Participant who is not sufficiently fluent in reading and understanding the French language to be able to consent to participate in the study
- •Participant unable to follow study procedures and to respect visits throughout the study period
- •Person with a medical history that, in the opinion of the investigator, could interfere with the results of the study
- •Any condition that, in the opinion of the investigator, could increase and compromise the safety of the person in the event that he / she participates in the study
- •Any other reason that, in the opinion of the investigator, could interfere with the evaluation of the aims of the study
研究组 & 干预措施
Control participants
Healthy individuals
干预措施: Evaluation of cognitive task on static balance (Other)
Patients with COPD
Patients with chronic obstructive pulmonary disease
干预措施: Evaluation of cognitive task on static balance (Other)
Patients with COPD
Patients with chronic obstructive pulmonary disease
干预措施: Evaluation of visual feedback on static balance (Other)
Control participants
Healthy individuals
干预措施: Evaluation of visual feedback on static balance (Other)
结局指标
主要结局
Difference of the range of COP displacement between groups and experimental conditions
时间窗: 10 minutes
Range of COP displacement correspond to the maximal amplitude of the path of COP in anteroposterior and mediolateral directions.
次要结局
- Difference of Sample Entropy (SampEn) of COP displacement between groups and experimental conditions(10 minutes)
- Difference of total COP displacement between groups and experimental conditions(10 minutes)
- Difference of area of COP displacement between groups and experimental conditions(10 minutes)