Comparative study of human choroidal structure by different OCT machines - Choroidal structure by OCT

Results:Forty-three subjects (mean age 30.5 years) were enrolled. Of 43 the eyes, SCT of 39 eyes (90.7%) could be measured using each machine. Intra-class correlation coefficients (95% confident interval) were 0.976 (0.954-9.987), 0.958 (0.919-0.978) and 0.939 (0.895-0.971) with Spectralis, Cirrus, and Topcon respectively. Inter-rater correlation coefficients (95% confident interval) were 0.944 (0.893 to 0.971), 0.956 (0.831 to 0.983) and 0.924 (0.825 to 0.964) with Spectralis, Cirrus, and Topcon respectively. The average SCT was 272.6, 272.8, and 269.2 &micro;m with Spectralis, Cirrus, and Topcon, respectively. Inter-machine correlation coefficient was significantly high among the machines (P<0.001, Spearman); 0.97 (Spectralis-Cirrus), 0.96 (Cirrus-Topcon) and 0.98 (Topcon-Cirrus). Bland-Altman plot analysis showed no typical trend among the machines.Conclusions:SCT measurements obtained with 3 different SD-OCTs were highly correlated and could be used interchangeably.