The Impact of Meal Timing on Neurovascular Control in Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Blood Pressure measured continuously over a period of 24 hour
研究概览
简要总结
Brain blood flow, blood pressure, and neurovascular control mechanisms will be measured in middle-aged adults before and after a brief intervention period. The intervention will consist of changing the time in which the participant consumes food each day.
详细描述
Healthy adults experience a 10-20% decrease in night-time blood pressure, compared with day-time blood pressure. However, 20-40% of middle-aged adults do not demonstrate a decrease in blood pressure. Abnormal blood pressure patterns are linked to sleep disturbances, hypertension, and associated with elevated cardiovascular risk and mortality. Additionally, abnormal diurnal blood pressure patterns are associated with impaired neurovascular control of the circulation, contributing to an increased risk of hypertension, stroke, and cardiovascular disease. Importantly, midlife is the critical period for implementing interventions to prevent or delay future cardiovascular disease. Recent data demonstrates that time-restricted feeding may normalize blood pressure patterns. The overall goal of this study is to determine if time-restricted feeding normalizes blood pressure patterns and improves neurovascular control.
The research aims are:
- To determine the effect of meal timing on blood pressure patterns in middle-aged adults.
- To determine the effect of meal timing on neurovascular control in middle-aged adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI ≤ 34 kg/m2
- •Non-smoking
- •Sedentary or recreationally active
- •≤ 2 Alcoholic drinks per day
- •Female subjects: Perimenopausal/Postmenopausal
排除标准
- •History or evidence of hepatic, renal, hematological, peripheral vascular disease, or stroke/neurovascular disease, diabetes, uncontrolled hypertension, sleep apnea
- •On medications used to treat/manage diseases listed above
- •Work overnight shifts
- •Clinically diagnosed anxiety or depression
- •Pregnant or trying to become pregnant
- •Significant surgical history
- •Other significant medical conditions at investigator's discretion
研究组 & 干预措施
Time-Restricted Feeding
Control (Baseline): Blood pressure and neurovascular control will be measured.
Post-Intervention: Blood pressure and neurovascular control will be measured.
干预措施: Time-Restricted Feeding (Behavioral)
结局指标
主要结局
Blood Pressure measured continuously over a period of 24 hour
时间窗: Continuously over a 24-hour period
Utilize an ambulatory blood pressure monitor to measure blood pressure values continuously over a 24-hour period.
Neurovascular Control: Change in the brain blood flow
时间窗: Baseline and 5 weeks
Change in brain blood flow will be measured using a transcranial Doppler ultrasound in response to a breathing test.
Neurovascular Control: Change in the blood pressure
时间窗: Baseline and 5 weeks
Change in blood pressure in response to a breathing test.
Neurovascular Control: change in the sympathetic nerve activity
时间窗: Baseline and 5 weeks
Change in sympathetic nerve activity will be measured using microneurography in response to a breathing test.
次要结局
未报告次要终点