Mind the Heart: Best Practices for Prevention, Early Identification and Treatment of Mood and Anxiety Disorders in Men With Heart Disease

The intervention proposed in this study is a stepped-care model comprised of three steps. The intensity of the intervention increases for participants with each of the following steps: 1) psychoeducation, 2) group therapy and 3) individual therapy. Recent evidence has shown the need for more tailored assessment and treatment methods for men suffering from depression as well as evidence showing the effectiveness of EFT (Emotionally-Focused Therapy)1. As such, the stepped-care model approach will be based on cognitive-behaviour therapy (CBT) and Emotionally-Focused Therapy (EFT). The research design is based on a quasi-experimental paradigm and a prospective observational cohort study.

Background information In 2012, the Canadian Institute for Health Information estimated that 6.8 million Canadians age 20 to 74 are affected by the following chronic conditions heart disease, high blood pressure, diabetes, asthma, and chronic obstructive pulmonary disease. Strikingly, nearly 40% more men than women are likely to be hospitalized for all types of heart disease (HD) combined2. Mental health and physical health are fundamentally linked. It is three times more likely that a person with HD will experience depression when compared to people without HD2. Research on men's mental health in the context of HD, specifically in acute coronary syndrome (ACS), reveals an important relationship between HD and mood disorders, anxiety disorders, and trauma-related stress in men (MD/AD/TRS)3. Co-existing HD and mental illness contribute to worse health status and higher health care utilization rates3. This is problematic because men underuse mental health services and health services in general4. The principal reasons evoked to explain this are the lack of "male-friendly" health services, the functional view that men have of their bodies, and their perception of healthcare services as occasional "fix-it" cures4. Thus, while men appear to be at high risk for HD and for the spectrum of MD/AD/TRS that often accompany it and slow the rehabilitation from ACS, they are unlikely to receive preventative services, to seek and to receive appropriate timely interventions for their psychological distress and mental illness. This in turn, can jeopardize men's mental health, quality of life and physical health over the long term, along with their life expectancy. Indeed, the occurrence of MD/AD/TRS has been shown to impact the prognosis of ACS patients.

In the context of this study an Acute coronary syndrome (ACS) encompasses multiple heart diseases having symptoms consistent with acute myocardial ischemia, including unstable angina and myocardial infarctions (MI) ("heart attacks") such as non-ST-segment elevation myocardial infarction (NSTEMI) and ST-segment elevation myocardial infarction (STEMI)5. On the other hand, Mood disorder or depressive disorders (MD) includes a variety of depressive conditions that mainly cause an individual to not function normally from a mental and physical standpoint. These conditions all show symptoms of sadness, emptiness and irritable mood6. Anxiety disorders (AD) consist of the anticipation of future threats, which cause an individual to be overly cautious or avoidant and result in such actions as misguided or anticipatory muscle tension in normal-considered situations6. Trauma-related stress (TRS) describes a condition where the individual's exposure to an event has caused unusual, physical or mental, stress or trauma. The aftermath of these events can vary; with some having the individual experiences anxiety and fear, but more often they will show a hedonic, dysphoric, dissociative and aggressive symptoms6.

Relevant Literature and Data The psychological effects of HD are seen at the patient level and their family (e.g. intimate partner)7-12. HD is related to decrease in sexual activity and sexual satisfaction, decrease in effective interpersonal communication, and increase in the amount and intensity of conflict in couple relationships13,14. This can be especially problematic for men, because they tend to become more intensely physiologically aroused (e.g., increase in blood pressure, cardiac reactivity, and limbic activation) for more extended periods of time during and after conflicts with their partners than do women15, which tends to lead them to shut down emotionally and to shut out their relationship partner in an attempt to re-establish psychological and physiological homeostasis16-18.Unfortunately, this type of "stonewalling"15 behaviour usually only serves to exacerbate couple conflict and leads to distressed conjugal relationships16-18. Clinically significant symptoms of depression and anxiety are known correlates of conjugal distress19-21. Furthermore, emotional isolation is also a known risk factor for the development of TRS22,23. Patients with MD/AD/TRS are at greater risk (two-fold) of major adverse cardiac events than those without24; and at risk of recurrent HD and mortality25. All of this may contribute to poorer prognosis of ACS patients with MD/AD/TRS.

Despite findings from some small-scale studies that indicate positive effects of psychotherapy and pharmacological therapy on symptoms of depression and anxiety in the context of HD26-28, the results of large controlled trials are equivocal. The Enhancing Recovery in Coronary HD Patients (ENRICHD) study investigated MD, HD, social support and CBT29-32. Their finding showed that CBT helped to reduce symptoms of depression in MI patients in short term but the benefits waned after 30 months. Similarly, the Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) study suggested that 12 weeks of Interpersonal Therapy (IPT) did not add to the effects of clinical management on depression in cardiac patients when combined with the antidepressant citalopram33. The psychological treatments that have been used to date thus appear to be lacking for cardiac patients with depression, which emphasizes the need for the development of ones that will have the desired effects on their psychological symptoms. Aside from the handful of studies cited above, published reports of treatments/care of MD/AD/TRS in the context of HD are virtually nonexistent. Thus far, all of the research in this area has focused on generic treatments for men and women that might neglect the specific needs or tendencies of either gender in terms of mental-health treatment.