Effect of Beetroot Juice on Body Composition, Physical Function, Muscle Strength, and Peak Oxygen Consumption in Resistance Trained Older Adults Consuming a Protein Supplement
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 主要终点
- Whole body fat free mass
研究概览
简要总结
The present study compared the effects of a nitrate containing beetroot juice supplement (BRJ+Nitrate) vs. a placebo (Control) on total and regional fat free mass, quadriceps muscle strength, lower body mobility, and VO2peak in healthy, older adults undergoing a 10-week long progressive resistance training program with protein supplementation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
A third party not involved with the conduct of the study provided research staff with the beetroot juice in participant specific coded bottles. The research staff then distributed these coded bottles to the participant. At the end of the trial, the code was revealed for intervention assignment.
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Able to provide own transportation to study testing visits and intervention
- •Able to read and write in English
- •Nondiabetic, i.e. fasting glucose < 126 mg/dl
- •Sedentary (less than 60 minutes of moderate intensity structured physical activity each week and occurs in no more than 10 minute blocks and not participating in a resistance exercise training program)
- •Willingness to provide informed consent and participate in intervention. Participants with diagnosed depression were permitted to participate provided that they have been medically stable without medication change for at least 3 months.
排除标准
- •Smoking or use of chewing tobacco
- •Involved in another intervention research study
- •Diabetic (type 1 or 2)
- •Atrophic gastritis
- •Hypo- or hyperthyroidism
- •Gout or history of kidney stones
- •History of hypotension
- •Premenopausal (women)
- •Aversion to study-related testing procedures
- •Allergy/sensitivity/aversion to beetroot beverages or protein supplement
- •Medical conditions with contraindications for engaging in resistance training program or taking the protein supplement
- •Systemic, uncontrolled diseases (diabetes, recent (last 6 months) or current treatment of cancer, thyroid disorders, cardiovascular disease, COPD, or inflammatory bowel diseases)
- •Use of any of the following medications: phosphodiesterase type 5 inhibitors, nitroglycerin or nitrate preparations, proton pump inhibitors, or medications for hypothyroidism
- •Potential inability to complete the tasks required for the protocol as well as conditions that may interfere with interpretation of results including: inability to ambulate, severe congestive heart failure or severe cardiovascular disease, neoplasm for practical and neurophysiologic reasons
- •Individuals with contraindications for performing a graded exercise test or have medical contraindications for participating in a scheduled exercise training program
- •Individuals more than 300 pounds or less than 125 pounds due to DEXA weight limits and possibility of exceeding recommended daily nitrate dose of 7 mg/kg body weight, respectively.
结局指标
主要结局
Whole body fat free mass
时间窗: Collected at 10-weeks
mass of fat free tissue
Whole body fat mass
时间窗: Collected at 10-weeks
Mass of fat tissue
Thigh muscle
时间窗: Collected at 10-weeks
Volume of thigh muscle
Thigh intermuscular fat
时间窗: Collected at 10-weeks
Volume of fat in the thigh muscle
Thigh subcutaneous fat
时间窗: Collected at 10-weeks
Volume of subcutaneous fat in the thigh
Visceral fat
时间窗: Collected at 10-weeks
Volume of visceral fat
Muscle strength
时间窗: Collected at 10-weeks
Strength of quadriceps muscle at a speed of 60 degrees per second
400 meter walk
时间窗: Collected at 10-weeks
Time to walk 400 meters
Stair climb time
时间窗: Collected at 10-weeks
Time to ascend and descend 12 stairs
Peak oxygen consumption
时间窗: Collected at baseline
Peak oxygen consumed at maximal exercise during graded exercise testing
次要结局
未报告次要终点
研究者
Gary Miller
Professor
Wake Forest University