Efficacy of injectable platelet rich fibrin iPRF with topical 5 percent minoxidil versus microneedling with topical 5 percent minoxidil in male androgenetic alopecia A tertiary care hospital based randomised controlled trial
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Change in hair density as indicated by hair count/cm2 by trichoscopy.
研究概览
简要总结
As PRP is an established treatment option for androgenetic alopecia, and injectable platelet rich fibrin is a 2 nd generation PRP which has been found to have higher concentration of growth factors as compared to PRP, we are comparing the efficacy of injectable platelet rich fibrin ( iPRF) vs microneedling (as a standard comparator) in androgenetic alopecia. Patients will undergo monthly sessions of iPRF or microneedling respectively for 6 months and further follow up will be done for a further 6 month period. Moreover, minoxidil 5 % will be applied by patients of both the arms of the trial twice daily. We will assess hair count by trichoscopy at 0,6 months and 12 months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- Male
入选标准
- •Androgenetic alopecia Norwood Hamilton grade III- V No history of treatment with PRP or Finasteride in the past 6 months.
- •No history of minoxidil oral or topical for at least 2 months prior to study.
排除标准
- •Active scalp infections or skin diseases (psoriasis, eczema).
- •Known hypersensitivity to minoxidil or any other study components.
- •Prior hair transplantation.
- •Any coagulation disorder or thrombocytopenia.
结局指标
主要结局
Change in hair density as indicated by hair count/cm2 by trichoscopy.
时间窗: At 0, 6 and 12 months.
次要结局
- Difference between the response of injectable platelet rich fibrin (iPRF) and microneedling in different stages of androgenetic alopecia.(maintainence period of response achieved for a further 6 month follow up period.)
研究者
Farkhanda Sofi
ALL INDIA INSTITUTE OF MEDICAL SCIENCES GORAKHPUR