The Effect of Simvastatin With Guided Bone Regeneration on Ridge Volume in Ridge Splitting and Simultaneously Implantation: a Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- Measurements of the amount of bone formation in millimeters around immediately placed dental implants
研究概览
简要总结
Ridge split augmentation technique, with immediate implant placement, reduces the time of the treatment and the time of the final prosthetic reconstruction. Furthermore, compression of the bone increases its density. SMV is also found to promote osteogenic differentiation of bone marrow stem cells, suppress osteoclastic differentiation in bone tissue, and promotes osseointegration around implants in animal studies. The aim of this study is to compare surgical outcomes of the application of the alveolar ridge splitting (ARS) in combination with guided bone regeneration (GBR) using bone grafting and a barrier membrane, associated with immediate implant placement versus ARS in combination with the use of SMV with GBR using bone grafting and a barrier membrane, associated with immediate implant placement in patients with horizontally atrophic jaw bones.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •good general health at the time of surgery.
- •at least 3 months of healing after tooth extraction.
- •horizontally compromised alveolar ridges at least 10 mm high and 3 mm wide.
排除标准
- •a vertical bone defect in the edentulous ridge.
- •thick cortex in the labial/buccal with less cancellous bone inside
- •obvious undercut on the labial/buccal side.
- •uncontrolled periodontal conditions or other oral disorders.
- •history of radiotherapy in the head and neck region.
- •uncontrolled diabetes mellitus or other systematic disorders.
- •Pregnancy.
- •non-compliant patients.
- •allergic reaction to the medications used.
结局指标
主要结局
Measurements of the amount of bone formation in millimeters around immediately placed dental implants
时间窗: 9 months
Measurements of the amount of bone formation in millimeters using GBR with or without the combined effect of SMV in the ridge splitting following immediate implant placement.
次要结局
未报告次要终点
研究者
Dalia Rasheed Issa
principle investigator
Kafrelsheikh University