Effect of Goal-directed Fluid Therapy Based on Stroke Volume Variation on Metabolic Acidosis in Patients Undergoing Brain Tumor Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Standard base excess point
研究概览
简要总结
In patients undergoing craniotomy, 0.9% normal saline is commonly administered in order to reduce cerebral edema. Excessive administration of 0.9% normal saline has been to reported to cause hyperchloremic metabolic acidosis. On the other hand, hypovolemia due to insufficient fluid replacement for perioperative loss can also result in metabolic acidosis by lactic acid accumulation. However, the guideline for perioperative fluid management has not been yet established. The investigators hypothesized that intraoperative fluid management according to SVV(Stroke Volume Variation)could reduce perioperative metabolic acidosis compared to those by CVP(Central Venous Pressure). Therefore, the study is trying to determine if intraoperative fluid administration based on SVV could reduce metabolic acidosis when compared with CVP in patients undergoing craniotomy due to brain tumor who receive 0.9% normal saline as main fluid regimen.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing craniotomy due to brain tumor
- •American Society of Anesthesiologists physical status I or II
- •aged from 20 to 65
排除标准
- •compromised cardiopulmonary function
- •diabetes mellitus
- •symptom or sign with increased intracranial pressure
- •liver or renal disease
- •pre-existing metabolic acidosis
- •pregnant or breast-feeding
- •patients who cannot understand the statements for subjects
研究组 & 干预措施
group C
intraoperative fluid management based on CVP
干预措施: CVP (Drug)
group S
intraoperative fluid management based on SVV
干预措施: SVV (Drug)
结局指标
主要结局
Standard base excess point
时间窗: at the suturing of scalp
次要结局
未报告次要终点