Prospective Study of Mycobacterium Tuberculosis Specific Cellular immune Responses in Iatrogenically Immunosuppressed Patients: those undergoing TNF-alpha blockade or Awaiting Renal Trasnplants: A Potential New Method For Accurate Diagnosis of Latent Tuberculosis Infection in Clinical Practice - Diagnosis of Latent TB Infection in Anti-TNF alpha or Dialysis

niversity of Oxford0 个研究点目标入组 520 人开始时间: 2005年12月15日最近更新: 2020年7月27日

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•Patients in chronic renal failure who are potential transplant recipients
•Patients with a rheumatological condition who are potential recipients of Tumour Necrosis Factor alpha blockade
•adult (over 18)
•able to give written informed consent
•with risk factors for tuberculosis:
•-[renal arm] from collaborating units in high prevalence areas of the UK
•-[anti TNF alpha arm] patients who would be considered for tuberculin skin testing under current anti-TNFalpha treatment guidelines, including past history of exposure or disease, immigrant from high prevalence area, CXR changes suggestive of prior TB, grade 2 heaf test or above
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

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