The Effect of Intermittent Theta-Burst Stimulation on Motor Cortical Plasticity, Blood Glucose, and Cardiovascular Response in Healthy Young Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Motor evoked potential (MEP)
研究概览
简要总结
Transcranial magnetic stimulation is a medical device that can alter motor cortical (M1) excitability through the scalp via various protocols. Among these, intermittent theta-burst stimulation (iTBS) is a novel protocol that enhances the M1 excitability for several minutes beyond stimulation. The changes in M1 excitability might in turn be accompanied by other physiological responses in the human body. This study will explore the effect of iTBS protocol on M1 plasticity, heart rate, blood pressure, and blood glucose in healthy young adults in comparison to sham stimulation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Motor evoked potential (MEP)
时间窗: Pre-iTBS (baseline) and post-iTBS at 5,10,20, and 30 minutes
Peak-to-peak MEP amplitude elicited by single-pulse TMS over the left M1 representation of the first dorsal interosseous (FDI) muscle. In each MEP measurement throughout the study, a total of 12 MEP readings, elicited by single pulse TMS at an intensity of 120% resting motor threshold, and separated by 15 seconds, will be collected. In each time point post-iTBS, the mean value of MEPs (aka, conditioned MEPs) will be averaged and compared to pre-iTBS (aka, baseline MEPs) using the following equation: (conditioned MEP amplitude/baseline MEP amplitude) × 100. A value of 90-110% represents no change, while values \< 90% represent suppression, and \> 110% represent facilitation of the M1 plasticity following iTBS.
次要结局
- Heart rate(Pre-iTBS (baseline) and post-iTBS at 0 and 30 minutes)
- Blood glucose(Pre-iTBS (baseline) and post-iTBS at 0 and 30 minutes)
- Blood pressure(Pre-iTBS (baseline) and post-iTBS at 0 and 30 minutes)
- Baseline corticospinal excitability indices(Baseline)
- TMSens_Q questionnaire(At the end of every session)
研究者
Wan Aliaa Wan Sulaiman
Principal Investigator
Universiti Putra Malaysia