Race Differences in 24-hour Energy Expenditure, Substrate Oxidation, and Appetite in Adolescent Girls
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Sedentary Day Substrate oxidation
研究概览
简要总结
This study will examine race differences in total energy expenditure and respiratory quotient (RQ) during and after exercise, compared to a sedentary control condition, in adolescent girls who are classified as overweight. In addition, subjective appetite and objective energy intake will be measured throughout the assessment periods.
详细描述
Aim 1: Measure 24-hour energy expenditure and its components (resting, activity, and sleep energy expenditure) and compare differences between African-American and White girls.
Hypothesis
Total, resting, and sleep energy expenditure will be lower in African-American relative to White girls. Activity energy expenditure will be equivalent per the study design.
Aim 2: Measure and compare substrate oxidation and associations with appetite (i.e., hunger, desire to eat) and energy intake between African-American and White girls.
Hypothesis
African-American girls will have a higher RQ at rest, during exercise, and following exercise, and RQ will be positively associated with subjective appetite ratings and energy intake.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 13 Years 至 17 Years（Child）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Age 13-17 years, inclusive
- •Achieved menarche based on parent- and/or self-report
- •Overweight based on BMI percentile for age and sex (≥ 85th and < 95th)
- •Self-identification as non-Hispanic White or African-American
- •Willing to maintain current physical activity, sleep schedule, and dietary habits during the study
- •Willing to comply with study procedures
排除标准
- •Contraindications to exercise testing as defined by the American College of Sports Medicine (i.e., medical history of cardiovascular, pulmonary, or physical conditions that affect the ability to exercise)
- •Food allergies
- •Dietary restrictions
- •Unwilling to consume study foods
- •History of polycystic ovary syndrome (PCOS)
- •Current amenorrhea or other menstrual cycle irregularities
- •Pregnant or currently breastfeeding
- •Current anemia
- •Use of medications affecting metabolism or sleep
- •Inability to properly or safely complete the study procedures per the investigators' discretion
结局指标
主要结局
Sedentary Day Substrate oxidation
时间窗: 24 hours on Sedentary Day
Non-protein respiratory quotient (i.e., carbohydrate and fat utilization) as measured by the metabolic chamber
Exercise Day Substrate oxidation
时间窗: 24 hours on Exercise Day
Non-protein respiratory quotient (i.e., carbohydrate and fat utilization) as measured by the metabolic chamber
Sedentary Day Energy expenditure
时间窗: 24 hours on Sedentary Day
Total energy expenditure and its components (sleeping, wake \[non-exercise\], activity) as measured by the metabolic chamber
Exercise Day Energy expenditure
时间窗: 24 hours on Exercise Day
Total energy expenditure and its components (sleeping, wake \[non-exercise\], activity) as measured by the metabolic chamber
次要结局
- Sedentary Day Appetite(24 hours on Sedentary Day)
- Exercise Day Appetite(24 hours on Exercise Day)
- Exercise Day Energy Intake(24 hours on Exercise Day)
- Sedentary Day Energy Intake(24 hours on Sedentary Day)
研究者
Eric Ravussin
Professor
Pennington Biomedical Research Center