Clinical Metabolomics investigation of Rheumatoid Arthritis patients receiving Ayurvedic whole system intervention

Rheumatoid Arthritis (RA) is an autoimmune musculoskeletal disorder having a high prevalence and debility potential. Its treatment conventionally aims at early diagnosis followed by symptom management, deformity and joint destruction prevention, restoration of joint mobility and quality of life improvement. ’Clinical Metabolomic’ in RA is one step head of conventional assessment done through clinical observations generic biomarkers like ESR & CRP. Purpose of this study is to find if there are any meaningful differences among ’RA related disease activity specific metabolites’ in sample population of RA receiving ayurvedic whole system intervention considering its own method of diagnosis & treatment selection. Intervention will be given for 3 months. A 2 weekly follow-up will be done for the purpose of clinical records. Metabolomics will be performed only pre and post i.e., at the time of registration & after completion of trial. A patient population of 30 RA considering the single group & pragmatic nature of the study having a simultaneous diagnosis of Amavata and receiving specific ayurvedic comprehensive interventions (whole system approach) for 3 months will be evaluated clinically on the basis of DAS-28 score changes and will be categorized for level of improvements as ACR20, ACR50 or ACR70. This clinical outcome assessment will be supplemented by quantitative evaluation of inflammatory markers like ESR/CRP.