Effects of Thai Dance Meditation Exercise on Renal and Cerebrovascular Function in Elderly With Diabetic Kidney Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Stroop test
研究概览
简要总结
Elderly with diabetic kidney disease who practiced Thai dance meditation training more favorable adaptations than normal daily life in improving glycemic control, kidney function, vascular function and cerebrovascular function.
详细描述
This cross-sectional study was to compare glycemic control, kidney function, vascular function, cerebrovascular function, physical fitness and quality of life between elderly with diabetic kidney disease who practiced Thai dance meditation training and normal daily life.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The inclusion criteria included diabetic kidney disease (DKD) (as defined by the KDIGO (Kidney Disease Improving Global Outcomes 2012), a baseline glycosylated hemoglobin (HbA1c) value of 7-9%, albumin-to creatinine ratio (ACR): A3 [>300 mg/day; ACR, >300 mg/g (>30 mg/mmol)], GFR category 3 (moderately decreased) has now been divided into categories G3a [45-59 mL/ min1 /(1.73m2) and G3b [30 -44 mL/ min1/(1.73 m2) which represent mildly to moderately decreased function and moderately to severely decreased function and no previous exercise training in the past 6 months.
- •All participants were free from diabetic retinopathy, severe diabetic neurophathy, severe cardiovascular and cerebrovascular diseases.
- •Participants had Montreal Cognitive Assessment - Thai (MoCa-T) scores between 18 24 points.
- •Not having uncontrolled high blood pressure (Systolic blood pressure; SBP) >159 mmHg and Diastolic blood pressure; DBP) > 99 mmHg
排除标准
- •Participants were excluded if they dropped out or completed less than 80% of the training schedule
结局指标
主要结局
Stroop test
时间窗: Change from baseline Stroop test in second at 12 weeks.
Stroop test in second will be measured with EncephalApp - Stroop Test
Intrarenal artery
时间窗: Change from baseline renal arterial resistive index (RI) at 12 weeks.
Intrarenal artery will be measured by renal blood flow in renal arterial resistive index (RI) with ultrasonography equipment EPIQ 5G, Phillips.
Cerebrovascular reactivity index
时间窗: Change from baseline cerebrovascular reactivity index at 12 weeks
Cerebrovascular reactivity index in %cm/sec/mmHg will be measured with ultrasonography equipment (EPIQ 5G, Phillips).
Arterial compliance
时间窗: Change from baseline Arterial compliance at 12 weeks
Arterial compliance in units will be measure by carotid diameter during systolic and diastolic with ultrasonography equipment (EPIQ 5G, Phillips) and systemic blood pressure with (VP-1000 plus, omrom Healthcare).
Body fat
时间窗: Change from baseline body fat at 12 weeks
Body fat in percent will be measured with dual energy x-ray absorptiometry in percent (Prodigy-Pro, GE healthcare).
Muscle mass and Weight
时间窗: Change from baseline muscle mass and weight at 12 weeks.
Muscle mass and weight in kilograms will be measured with dual energy x-ray absorptiometry in kilogram (Prodigy-Pro, GE healthcare).
Arterial stiffness
时间窗: Change from baseline brachial-ankle pulse wave velocity at 12 weeks
Arterial stiffness will be measured with brachial-ankle pulse wave velocity in centimeter per second (VP-1000 plus, omrom Healthcare).
Cerebral blood flow
时间窗: Change from baseline cerebral blood flow at 12 weeks
Cerebral blood flow in centimeter per second will be measure with ultrasonography equipment (EPIQ 5G, Phillips).
Cerebrovascular conductance index
时间窗: Change from baseline cerebrovascular conductance index at 12 weeks
Cerebrovascular conductance index in cm/sec/mmHg will be measured with ultrasonography equipment (EPIQ 5G, Phillips).
Montreal Cognitive Assessment
时间窗: Change from baseline Montreal Cognitive Assessment at 12 weeks.]
Montreal Cognitive Assessment in score (0 - 30 scores) cut off below 25 scores that indicate impairment cognitive function.
estimate Glomerular filtration rate
时间窗: Change from baseline estimate Glomerular filtration rate at 12 weeks.]
estimate Glomerular filtration rate in ml/min/1.73 m2 will be calculated by CKD-EPI formular according to National kidney foundation recommendation.
Cystatin C
时间窗: Change from baseline blood urea nitrogen at 12 weeks
Cystatin C in mg/L will be measure with particle enhanced Immunoturbidimetric assay
Blood pressure
时间窗: Change from baseline systolic blood pressure, diastolic blood pressure, and mean arterial pressure at 12 weeks.]
Blood pressure (systolic blood pressure, diastolic blood pressure, and mean arterial pressure) in mmHg will be measured with automated blood pressure in mmHg device (CARESCAPE V100, GE Dinamap).
Macro vascular function
时间窗: Change from baseline brachial artery flow-mediated dilatation at 12 weeks
Macro vascular function will be measured by brachial artery flow-mediated dilatation in percent with ultrasonography equipment EPIQ 5G, Phillips.
Pulsatility index
时间窗: Change from baseline Pulsatility index at 12 weeks.] 12.Montreal Cognitive Assessment
Pulsatility index in units will be measure with ultrasonography equipment (EPIQ 5G, Phillips).
Fasting blood sugar
时间窗: Change from baseline fasting blood sugar at 12 weeks.]
Fasting blood sugar in mg/dl will be measure with enzymatic assay using hexokinase reaction.
Heart rate
时间窗: Change from baseline heart rate at 12 weeks
Heart rate in beats per minute will be measured with automated blood pressure in beat per minute device (CARESCAPE V100, GE Dina map).
Renal function
时间窗: Change from baseline Blood urea nitrogen at 12 weeks.
Blood urea nitrogen (BUN) in milligram per deciliter will be measure by Kinetic test with urease and glutamate dehydrogenase with urease/glutamate dehydrogenase coupled enzymatic (Coupled enzymes)
Post Occlusive Reactive Hyperemia; PORH
时间窗: Change from baseline Post Occlusive Reactive Hyperemia; PORH at 12 weeks.
Evaluation of blood flow to the skin area in percent will be measured by Post Occlusive Reactive Hyperemia in percent; PORH with Laser Doppler flowmeter, Perimed AB, Sweden.
Trail Making Test-B
时间窗: Change from baseline Trail Making Test-B at 12 weeks
Trail Making Test-B in second cut off below 101 seconds that indicate dementia.
Urine albumin creatinine ratio
时间窗: Change from baseline urine albumin creatinine ratio at 12 weeks.
Urine albumin creatinine ratio will be measure with Immunoturbidimetric assay
Mini-Mental State Examination
时间窗: Change from baseline Mini-Mental State Examination at 12 weeks.]
Mini-Mental State Examination in scores (0 - 30 scores) cut off below 25 scores that indicate impairment cognitive function.
Glycosylated hemoglobin
时间窗: Change from baseline Glycosylated hemoglobin at 12 weeks.]
Glycosylated hemoglobin in percent will be measure with enzymatic assay using hexokinase reaction.
Homeostasis Model Assessment of insulin resistance
时间窗: Change from baseline Homeostasis Model Assessment of insulin resistance at 12 weeks.]
Homeostasis Model Assessment of insulin resistance in units will be calculated with Fasting blood sugar and insulin.
Creatinine
时间窗: Change from baseline creatinine at 12 weeks.]
Creatinine in mg/dl will be measure with enzymatic assay
次要结局
- Balance testing(Change from baseline time up and go at 12 weeks.])
- Quality of life in patients with chronic kidney disease(Change from baseline at 12 weeks.)
- .Flexibility testing(Change from baseline Chair sit & reach at 12 weeks.])
- Flexibility testing(Change from baseline back scratch at 12 weeks.)
- Waist circumference(Change from baseline waist circumference at 12 weeks])
- Cardiopulmonary fitness(Change from baseline 6-minutes walk at 12 weeks.])
- Interleukin-6 (IL-6), Tumor necrosis factor-alpha (TNF- α), Brain derived neurotrophic factor, Malondialdehyde, Superoxide Dismutase.(Change from baselineInterleukin-6 (IL-6), Tumor necrosis factor-alpha (TNF- α), Brain derived neurotrophic factor, Malondialdehyde, Superoxide Dismutase. at 12 weeks.])
- Nitric oxide(Change from baseline Nitric oxide at 12 weeks.)
- Body mass index (BMI)(Change from baseline BMI at 12 weeks.)
- Muscle strength testing(Change from baseline chair stand at 12 weeks.])
- Lipid profile(Change from baseline Nitric oxide at 12 weeks.] cholesterol, triglyceride, high density lipoprotein, and low density lipoprotein at 12 weeks.])
研究者
Prof. Dr.Daroonwan Suksom
Faculty of Sports science
Chulalongkorn University