JPRN-UMIN000012987已完成未知
Clinical trial of Tocilizumab for adult onset still disease - Clinical trial of Tocilizumab for adult onset still disease
Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine0 个研究点目标入组 34 人开始时间: 2014年1月31日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 34
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1) Patients having received Inflixmab, Golimumab, Adalimumab, Apatacept, Leflunomide and Certolizumab pegol within 12 weeks 2) Patients having received Etanercept within weeks before starting treatment 3) Patients having received surgical treatment or plasmapheresis within 4 weeks before starting treatment 4) Patients having received DMARDs or immune-suppressing drug within 2 weeks 5) Patients having changing the dose of corticosteroid within 2 weeks 6) Patients having received cell depletion therapy before participation in this study 7) White blood cell count <3x10^9/L 8) Neutrophil count <1,000/microliter 9) Platelet count <50x10^9/L 10) Lymphocyte count <500/microliter 11) ALP >five times of upper limit of facility criteria 12) Total Bilirubin >three times of upper limit of facility criteria 13) Patients with past history of serious allergy 14) Patients with drug allergy for Tocilizumab 15) Patients with serious disease 16) Patients with active tuberculosis 17) Patients with interstitial pneumonia 18) Patients with past history of HIV, hepatitis B and hepatitis C 19) Patients having received live vaccine within 6 weeks before treatment 20) Patients who have been diagnosed cancer within 5 years 21) Patients with current and past history of intestinal diverticulum 22) Patients with infection within 4 weeks 23) Patients having received the other drug within 6 months 24) Patients who cannot receive intravenous therapy 25) Patients with current history of alcoholics and drug dependence, or with past history of alcoholics and drug dependence within 24 weeks 26) Patients with a history of receiving Tocilizumab 27) Expecting mothers or mothers with breast-feeding 28) Patients who will not use any way of contraception 29) Others not applicable person determined by a doctor
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