Diagnosis of Bone Metabolism in Patients With Inexplicable Lower Back Pain
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Abnormal foci of elevated bone metabolism, blood pooling or bone perfusion
研究概览
简要总结
The main goal of this study is to determine if static or dynamic [18F]NaF PET/CT (positron emitting tomography) can identify the source of lower backpain in at least 20% of the patients experiencing lower backpain, yet could not be diagnosed from MRI or CT scans.
详细描述
Patients with chronic lower backpain are routinely scanned with MR and/or CT to diagnos the source of pain. Larger studies have reported that approximately 20% of patients are given a certain diagnosis from the scans and in the majority of cases the source of the pain is not determined. The use of [18F]NaF PET/CT to map bone perfusion and metabolism is a routine clinical scan that can potentially identify the source of lower backpain in MRI and CT negative patients.
Hypothesis
That [18F]NaF PET/CT bone metabolism and bone perfusion images would contain information that allow the correct diagnosis in at least 20% of patients where MRI and CT images did not reveal pathology.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Over 18 years
- •Chronic lower back pain with no concrete diagnosis after MRI and/or CT
- •Under the the care of Rigshospitalets centre for Rheumatology and Spine Disease
排除标准
- •previous operation in the lower back area
- •Known inflammatory related illness or progressive rheumatism
结局指标
主要结局
Abnormal foci of elevated bone metabolism, blood pooling or bone perfusion
时间窗: 1 hour examination
\[18F\]NaF PET/CT scan
次要结局
未报告次要终点
研究者
Rune Toennesen
Md, PhD
Rigshospitalet, Denmark