NCT03845244已完成不适用
Simultaneous Reduction Versus Flow or Fraction of Inspired Oxygen Reduction First in Patients Ready to Wean From High Flow Nasal Cannula Oxygen Therapy: a Randomized Controlled Trial
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Time to weaning success
研究概览
简要总结
High flow nasal cannula oxygen therapy has been widely used in critically ill patients. Despite effectiveness of high flow nasal cannula as a treatment, optimal methods to withdrawal high flow nasal cannula after recovery from preexisting conditions has not been investigated to date. In this study, we will evaluate the efficacy and safety of three different weaning methods in patients with high flow nasal cannula oxygen therapy.
详细描述
Comparison of three weaning strategies: flow reduction first versus fraction of inspired oxygen (FiO2) first versus simultaneous reduction
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The patients applying high flow nasal cannula and satisfying the following weaning criteria.
- •Patient who has recovered from the underlying condition
- •No signs of respiratory distress like agitation, diaphoresis or anxiety
- •Arterial pH ≥ 7.35, SpO2 > 90% on FiO2 ≤ 0.5
- •Respiratory rate ≤ 25/min, Heart rate ≤120/min, Systolic blood pressure ≥ 90mmHg
排除标准
- •Severe hypercapnia (pH <7.25)
- •Respiratory arrest requiring tracheal intubation
- •Cardiac arrest, acute coronary syndrome or life threatening arrhythmias
- •Failure of more than two organs
- •Recent trauma or burns of the neck and face
- •Non- cooperation
- •Pregnancy
- •Refusal of treatment
结局指标
主要结局
Time to weaning success
时间窗: up to 2 weeks
The time to successfully remaining off high flow nasal cannula
次要结局
- weaning success or failure rate(up to 2 weeks)
- change of arterial partial pressure of oxygen, carbon dioxide, and pH(up to 2 weeks)
- intolerance rate(up to 2 weeks)
- hospital length of stay(during hospital admission, up to 12 weeks)
- In-hospital mortality(during hospital admission, up to 12 weeks)
研究者
Eun Sun Kim
Associate professor
Seoul National University Bundang Hospital
研究点 (2)
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