Study of the Inappropriate Secretion of FGF23 in Patients Followed in Hospital in a Context of Hypophosphatemia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 260
- 试验地点
- 2
- 主要终点
- Evaluate the frequency of blood levels of FGF23 unsuitable for hypophosphatemia
研究概览
简要总结
The discovery of FGF23, the missing link in the long researched and finally found phosphate metabolism, marked a turning point in the understanding and physiopathology of specific hypophosphatemia. By inhibiting the renal reabsorption of phosphate and the production of calcitriol, FGF23 behaves like a hypophosphatemia hormone.
Hypersecretion of FGF23 can occur in the case of genetic abnormalities (X-linked hypophosphatemic vitamin-resistant rickets, recessive or dominant hypophosphatemic rickets, McCune-Albright syndrome ...) or acquired abnormalities (oncogenic osteomalacia). Oncogenic osteomalacia can be induced by hyperproduction of FGF23 by benign tumours of mesenchymal origin. But more recently, several cases of malignant tumours secreting FGF23 have also been described (prostate, colon, breast, ovarian and lung cancers, pulmonary carcinoma, etc.)
详细描述
To date, even if the incidence of FGF23-secreting tumours seems rare, no precise bibliographical data is available in the scientific literature. Future studies will have to address this issue in order not to underestimate the frequency of this complication.
In this context, investigators would like to study the incidence of inappropriate FGF23 increase from a collection of biological samples carried out on 500 patients treated at the Clermont-Ferrand University Hospital for hypophosphatemia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Major patient, male or female
- •Taken care of at the Clermont-Ferrand University Hospital or the Jean Perrin Centre
- •In a context of hypophosphatemia (< 0.80 mmol/L), without immediate anteriority and not occurring during hospitalisation
- •In capacity to express informed consent to participate in research
- •Affiliated to a social security system
排除标准
- •Previously diagnosed hypophosphatemia
- •Hypophosphatemia during hospitalisation
- •Haemodialysis patient
- •Refusal to participate
结局指标
主要结局
Evaluate the frequency of blood levels of FGF23 unsuitable for hypophosphatemia
时间窗: day 0
Assessing the presence of a blood level of FGF23 considered unsuitable for hypophosphatemia
次要结局
- Investigate the relationship between blood levels of FGF23 and other biochemical parameters in hospital patients with hypophosphatemia.(day 1)
- Investigate the relationship between blood levels of FGF23 and other biochemical parameters in hospital patients with hypophosphatemia..(Day 1)