Effect of Stimulant Drugs on Social Perception
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Responses to Affective Touch
研究概览
简要总结
The study will improve our understanding of the "prosocial" effects of ± 3,4-Methylenedioxymethamphetamine (MDMA), relative to a prototypical stimulant, methamphetamine (MA). The investigators seek to characterize the "uniquely social" effects of MDMA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •High school degree
- •English fluency
- •Has used MDMA
排除标准
- •Pregnant or trying to become pregnant
- •Any medical or psychiatry condition
研究组 & 干预措施
High dose MDMA
Subjects will attend one session during which they will receive 1.5mg/kg MDMA.
干预措施: 3,4-Methylenedioxymethamphetamine (Drug)
Placebo
Subjects will attend one session during which they will receive a placebo capsule.
干预措施: 3,4-Methylenedioxymethamphetamine (Drug)
Placebo
Subjects will attend one session during which they will receive a placebo capsule.
干预措施: methamphetamine (Drug)
Low dose MDMA
Subjects will attend one session during which they will receive 0.75mg/kg MDMA.
干预措施: 3,4-Methylenedioxymethamphetamine (Drug)
Low dose MDMA
Subjects will attend one session during which they will receive 0.75mg/kg MDMA.
干预措施: methamphetamine (Drug)
High dose MDMA
Subjects will attend one session during which they will receive 1.5mg/kg MDMA.
干预措施: methamphetamine (Drug)
Methamphetamine
Subjects will attend one session during which they will receive 20mg methamphetamine.
干预措施: 3,4-Methylenedioxymethamphetamine (Drug)
Methamphetamine
Subjects will attend one session during which they will receive 20mg methamphetamine.
干预措施: methamphetamine (Drug)
结局指标
主要结局
Responses to Affective Touch
时间窗: End of study (time 0 and approximately six weeks later)
Participants will complete an affective touch task during which time they will rate pleasantness of touch on a likert scale of 1-7, with higher scores indicating greater ratings of pleasantness
次要结局
未报告次要终点