Clinical Investigation of the Relationship Between Disease Severity and Periodontal Status in Patients With Pemphigus Vulgaris
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Oral Disease Severity Score (ODSS)
研究概览
简要总结
The aim of this study is to evaluate the relationship between the severity of Pemphigus Vulgaris (a chronic autoimmune skin disease) and periodontal (gum) health. Researchers will assess disease activity using the Oral Disease Severity Score (ODSS) for mouth lesions and measure serum Desmoglein 1 and 3 levels through blood tests. These findings will be compared with clinical gum measurements, such as pocket depth and attachment levels. The study intends to determine how the clinical and biochemical severity of Pemphigus Vulgaris impacts periodontal tissues and overall oral health.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 18 years and older.
- •Clinically and histopathologically confirmed diagnosis of Pemphigus Vulgaris.
- •Presence of at least 10 natural teeth.
- •Willingness to participate and signed informed consent.
排除标准
- •Pregnancy or lactation.
- •Use of systemic antibiotics or anti-inflammatory drugs within the last 3 months.
- •Periodontal treatment received within the last 6 months.
研究组 & 干预措施
Pemphigus Vulgaris Group
A comprehensive oral examination including ODSS scoring and periodontal measurements (PPD, CAL, PI, GI). Additionally, serum Desmoglein 1 and 3 levels will be retrieved from the patients' medical records for biochemical correlation.
干预措施: Clinical Periodontal and Oral Evaluation (Other)
结局指标
主要结局
Oral Disease Severity Score (ODSS)
时间窗: Baseline
A clinical scoring system used to assess the severity of oral mucosal involvement in patients with Pemphigus Vulgaris. It evaluates the site and extent of lesions in the oral cavity.
次要结局
- Serum Desmoglein 1 and 3 Levels(Baseline)
- Clinical Attachment Level (CAL)(Baseline)
- Probing Pocket Depth (PPD)(Baseline)
- Plaque Index (PI)(Baseline)
- Gingival Index (GI)(Baseline)
研究者
NURIYE ISIL SAYGUN
Professor, Department of Periodontology
Saglik Bilimleri Universitesi