Feasibility of Using Whole Body PET-MRI to Stage and Restage Paediatric and Adolescent Hodgkin Lymphoma - a Pilot Study
试验速览
- 阶段
- 不适用
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- The investigator will determine the technical feasibility of performing functional co-registered combined PET-MRI in this patient group using diffusion-weighted MR imaging.
研究概览
简要总结
Children and adolescents with Hodgkin lymphoma currently undergo multiple investigations including a separate PET and MRI scans during their treatment.
Investigators want to investigate if a combined PET-MRI scan could give the same information.
Children who join our study will have an extra scan twice during their treatment
详细描述
Children and adolescents with Hodgkin lymphoma currently undergo multiple investigations including a separate PET and MRI scans during their treatment.
Investigators want to investigate if a combined PET-MRI scan could give the same information.
Children who join our study will have an extra scan twice during their treatment
Routine whole body clinical MRI will be performed according to current clinical standard of care. Axial and coronal imaging from the maxilla to proximal femurs will be performed using a combination of T1 and T2 weighted sequences, with and without gadolinium administration.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 20 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Suspected or histologically confirmed Hodgkin lymphoma
- •Male or female participants
- •Age 0-20 years inclusive
- •Entered into the EuroNet PHL-C1 trial, LP1 trial or successor Euronet trials, including Euronet PHL C2 due to open from 2013 onwards or planned to receive chemotherapy regimens of said trials without being formally entered into the trial.
- •Participant/Guardian/Parental written informed consent
排除标准
- •Participants with contraindications to MRI (including cardiac pacemakers or non-MRI compatible intracranial vascular clips)
- •Participants who are pregnant or nursing
结局指标
主要结局
The investigator will determine the technical feasibility of performing functional co-registered combined PET-MRI in this patient group using diffusion-weighted MR imaging.
时间窗: 3 years
次要结局
未报告次要终点