Exposure to Particulate Matter on the London Underground in Healthy Subjects and Patients With Chronic Respiratory Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 83
- 试验地点
- 2
- 主要终点
- The difference (London Underground vs control exposure) in post exposure pulse wave velocity in healthy vs COPD participants.
研究概览
简要总结
An average of 4.8 million journeys are made on the London Underground every day and as the 'Tube' has elevated airborne particulate matter concentrations compared to ambient air, this raises concern about the potential health impact of this environment. This study explores the health effects of particulate matter from the London Underground on patients with COPD and healthy volunteers.
Patients with COPD and healthy participants will be invited to undertake a set 90 min journey on the London Underground, and on a separate occasion (3-8 weeks apart), a 90 min journey on the London Overground (as a proxy for a clean air London area while maintaining other aspects of a train journey). A series of clinical, physiological and inflammatory data will be collected before, during and after (at different time points) each of the sessions in order to compare their response in relation to exposure and/or to disease status.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
The difference (London Underground vs control exposure) in post exposure pulse wave velocity in healthy vs COPD participants.
时间窗: -2 hours, +2 hours, +5 hours, +6 hours, +24 hours
Measurement of arterial stiffness
次要结局
- Other clinical responses on the London Underground vs control exposure(-2 hours, +7 hours, +24 hours)
- Circulating inflammatory and oxidative responses after the exposure on the London Underground vs control exposure(-2 hours, +24 hours)