Ethnicity as a Determinant of Ovarian Aging: Differences Between Caucasian and Indian Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 400
- 主要终点
- AMH levels produced by granulosa cells
研究概览
简要总结
The investigators want to carry out a prospective study of 400 infertile Caucasian and Indian women who will undergo a controlled ovarian stimulation for in vitro fertilization (IVF). The investigators will collect data about ovarian reserve markers and also the results after ovarian stimulation in both ethnic groups.The aim is to identify differences in ovarian response after IVF stimulation between both groups.
详细描述
A total of 200 Caucasian patients and 200 Indian patients who will attend the first or second IVF cycle will be included.
The date we will collect in both groups include the age, the body mass index, and the ovarian reserve markers like the antral follicle count (AFC), the follicle stimulation hormone (FSH) and antimullerian hormone (AMH) serum levels.
The investigators will also determine the number of oocytes retrieved and the metaphase two oocytes in both groups after IVF stimulation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 42 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women aged < 42 years old, with both ovaries present, undergoing a first or second IVF treatment due to male factor, tubal disease or previous failed intrauterine insemination (IUI).
排除标准
- •Women diagnosed of polycystic ovary syndrome according to Rotterdam criteria, endometriosis stage III-IV, or previous pelvic inflammatory disease.
结局指标
主要结局
AMH levels produced by granulosa cells
时间窗: day 1
AMH levels (ng/mL) as well as AFC in both ethnic groups.
次要结局
- Number of oocytes(day 1)
研究者
Juan A Garcia-Velasco
Juan A Garcia-Velasco, MD, Phd
IVI Madrid