Pre-implantation Genetic Testing for Monogenic Disease: Single Center Experience
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 76
- 主要终点
- Live birth rate (LBR)
研究概览
简要总结
This monocentric retrospective observational study aims to evaluate the efficacy of pre-implantation genetic testing for monogenic diseases (PGT-M). The effectiveness will be assessed in terms of live birth rate (LBR), cumulative live birth rate (CLBR) per couple, and abortion rate (AR). Considering how many cycles the participants have undergone to achieve a viable blastocyst. The secondary objective is to evaluate the incidence of aneuploidy in unaffected embryos, in order to understand the need for pre-implantation genetic testing for aneuploidy (PGT-A)in addition to PGT-M.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 34 Years 至 42 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients fertile or infertile that have undergone preimplantation genetic testing for monogenic diseases (PGTM).
排除标准
- •No exclusion criteria will be taken into consideration.
结局指标
主要结局
Live birth rate (LBR)
时间窗: 7 years of inclusion
LBR will be measured as a percentage
Abortion rate (AR)
时间窗: 7 years of inclusion
AR will be measured as a percentage
Cumulative live birth rate (CLBR) per couple
时间窗: 7 years of inclusion
CLBR per couple will be measured as a percentage
次要结局
- Aneuploidy(7 years of inclusion)