Study of the Prognostic Value of Musculoskeletal Ultrasound in Adults With Chikungunya
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Presence of sonographic signs observed during the initial scan: periarticular infiltration, effusion, positive Doppler, erosions.
研究概览
简要总结
Chikungunya is a viral disease transmitted by mosquitoes whose clinical feature is the early joint damage. Approximately 8% of patients have chronic arthropathy resembling to the rheumatoid polyarthritis. The EchoCHIK study we propose is in the context of the epidemic in Martinique which began in January 2014. It should give a better understanding of arthritis and juxtaarticular of CHIK and look for signs that may allow ultrasound predict the evolution of chronic arthropathy of CHIK.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age at onset of symptoms ≥ 45 years
- •Seen in consultation at the University Hospital of Fort-de-France
- •Suspected chikungunya infection (fever and sudden onset of joint pain affecting the wrists, hands, ankles or knees)
- •Duration of symptoms suggestive of infection chikungunya less than or equal to 10 days
- •Presence of joint pain on the day of inclusion
- •No history of inflammatory arthritis
- •Absence of steroidal or non-steroidal anti-inflammatory drugs taken within two weeks prior to inclusion
- •Ability to participate in the study throughout its duration (12 months)
- •Patient affiliated or beneficiary of a social health care.
- •Acceptance to participate in the study and monitoring proposed and signed informed consent
排除标准
- •Age at onset of symptoms <45 years
- •Duration of symptoms suggestive of chikungunya for more than 10 days
- •Lack of joint pain on the day of inclusion
- •History of inflammatory arthritis Nonsteroidal anti-inflammatory drugs or
- •Taking in the two weeks preceding the inclusion
- •Inability to participate in the study throughout its duration (12 months)
- •Patient is not affiliated or beneficiary of a social health care.
- •Refusal to participate in the study or to sign a consent
结局指标
主要结局
Presence of sonographic signs observed during the initial scan: periarticular infiltration, effusion, positive Doppler, erosions.
时间窗: enrollement visit
Progression to chronic form defined by the persistence or recurrence of muscle symptoms (myalgia) and joints (arthralgia, arthritis) more than two months after the onset of symptoms of acute phase.
次要结局
- Presence of clinical and sonographic signs observed at each visit: arthralgia, arthritis clinics, periarticular infiltration, effusion, positive Doppler erosions.(1 month, 3 month, 6 month and 12 month after the first symptoms of infection by chikungunya virus)