Levels of High-Sensitivity C-Reactive Protein in Heart Transplant Patients With and Without Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
- 主要终点
- hscrp levels
研究概览
简要总结
Inflammation plays a key role in the deterioration of chronic heart transplants. Periodontal disease is not limited to the tooth-supporting structures - it also contributes to systemic inflammation. This study explored whether periodontitis is associated with serum high-sensitivity C-reactive protein (hs-CRP) levels in heart transplant patients.
The study included 33 patients who had undergone heart transplantation at Baskent University Hospital. Clinical periodontal parameters were recorded, and blood samples were collected on the same day to measure serum hs-CRP.
详细描述
Of the 33 patients, 9 (27.3%) had periodontitis, 4 (12.1%) were periodontally healthy, and 20 (60.6%) had gingivitis. Serum hs-CRP was significantly higher in the periodontitis group than in the healthy and gingivitis groups (P = .006). hs-CRP also correlated positively with probing depth (r = 0.358; P = .041), clinical attachment level (r = 0.352; P = .045), and gingival recession (r = 0.422; P = .014).
Elevated hs-CRP in heart transplant patients was associated with periodontitis, supporting the value of regular periodontal visits after transplant.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 11 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who underwent heart transplant procedures at Baskent University Hospital
排除标准
- 未提供
结局指标
主要结局
hscrp levels
时间窗: day 1
serum hscrp levels were compared between the groups
hs-CRP levels
时间窗: Day 1
Serum hs-CRP levels were compared between the groups (periodontitis vs. periodontally healthy vs. gingivitis)
次要结局
未报告次要终点
研究者
Yasemin Sezgin
Associate professor
Baskent University