Effects of Time Restricted Fasting and Exercise on Cardiovascular Risks Among Sedentary Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 56
- 试验地点
- 2
- 主要终点
- Change of cardiovascular risk estimated by ankle-brachial index
研究概览
简要总结
This project will determine the independent and combined effects of aerobic exercise and time restricted fasting on cardiovascular risks among sedentary middle-aged and elderly adults. The online intervention period will be eight weeks. Before and after the intervention, arterial stiffness, cardiac autonomic nervous, body composition, glucolipid metabolism, sleep and eating habits, inflammatory reaction, sedentary behavior and physical activity level will be measured and compared between groups who are doing either aerobic exercise, time restricted fasting, both aerobic exercise and time restricted fasting, or who are in a control group. Adverse reaction, sleep and eating quality, life quality and adherence to the interventions and hunger/satiety will also be measured.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 45 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age: 45-69 years old Sedentary time ≥8 hours per day
- •Irregular exercise habits
- •No drugs affecting the outcome index were taken
- •No history of serious diseases
- •Sign the subject informed consent and agree to participate in this experiment.
排除标准
- •The range of body weight change in the last three months is more than 3kg
- •People taking weight-loss drugs
- •Participate in other experimenters 5 months before the experiment
- •Unable to adjust and follow the intervention schedule.
结局指标
主要结局
Change of cardiovascular risk estimated by ankle-brachial index
时间窗: From baseline to after 8 weeks intervention
Change of cardiovascular risk estimated by heart rate variability
时间窗: From baseline to after 8 weeks intervention
Change of cardiovascular risk estimated by pulse wave velocity
时间窗: From baseline to after 8 weeks intervention
Change of cardiovascular risk estimated by flow-mediated transition
时间窗: From baseline to after 8 weeks intervention
Change of cardiovascular risk estimated by cytokines level
时间窗: From baseline to after 8 weeks intervention
Fasting matrix metalloproteinases, norepinephrine, and neuropeptide Y cytokines level in blood
次要结局
- Sleep quality(From baseline to after 8 weeks intervention)
- Physical activity(From baseline to after 8 weeks intervention)
- Weight(From baseline to after 8 weeks intervention)
- body fat(From baseline to after 8 weeks intervention)
- Diet habits(From baseline to after 8 weeks intervention)
- Triglycerides in blood(From baseline to after 8 weeks intervention)
- Adherence to intervention(From baseline to after 8 weeks intervention)
- Lean body mass(From baseline to after 8 weeks intervention)
- Body fat percentage(From baseline to after 8 weeks intervention)
- Life quality(From baseline to after 8 weeks intervention)
- Cholesterol in blood(From baseline to after 8 weeks intervention)
- Diet in take(From baseline to after 8 weeks intervention)
- Body mass Index(From baseline to after 8 weeks intervention)
- Low density lipoprotein in blood(From baseline to after 8 weeks intervention)
- Sedentary activity(From baseline to after 8 weeks intervention)
- Inflammation level(From baseline to after 8 weeks intervention)
- High density lipoprotein in blood(From baseline to after 8 weeks intervention)
- Adverse reaction(From baseline to after 8 weeks intervention)
研究者
Jingwen Liao
Associate Professor
Guangzhou Sport University