Characterization and Epigenetics of Post-Partum Preeclampsia
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- methylation signature on circulating monocytes
研究概览
简要总结
This study will recruit women with post partum pre-eclampsia and match them to controls without postpartum pre-eclampsia to identify an epigenetic signature that is specific to women with post partum pre-eclampsia to help characterize the underlying pathophysiology of post partum pre-eclampsia.
详细描述
Preeclampsia (PEC) is a heterogeneous disease that complicates 5-8% of pregnancies. Approximately 10% of PEC patients will present with post-partum PEC without having developed the syndrome during the pregnancy (PP-PEC). Management of post-partum preeclampsia (PP-PEC) is challenging because many women do not seek care until neurologic symptoms result from severe-range elevated blood pressure. The pathogenesis and clinical characteristics of PP-PEC are understudied and poorly understood. Identifying clinical risk factors and biomarkers of PP-PEC would help to identify women at risk.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Post partum pre-eclampsia
- •Matching based on:
- •maternal age (years +/-3)
- •BMI (+/-5 points)
- •Ethnicity
- •Mode of delivery
- •Gestational age at delivery (+/7 days)
- •Smoking status
排除标准
- •Intrapartum pre-eclampsia
结局指标
主要结局
methylation signature on circulating monocytes
时间窗: 1 week post delivery
次要结局
未报告次要终点