跳至主要内容
临床试验/NCT04758754
NCT04758754招募中不适用

Active and Passive Exercise Training in Improving Vascular Function: Local vs Systemic Vascular Effect

University of Milan1 个研究点 分布在 1 个国家目标入组 36 人开始时间: 2023年12月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
36
试验地点
1
主要终点
Change from baseline in brachial artery flow mediated dilation

研究概览

简要总结

Maintaining an adequate state of vascular function is an important element for the maintenance of cardiovascular well-being. Several training plans involving both active and passive engagement by the muscles have been proposed with the aim of improving vascular function. At local level, i.e., at the level of the arteries that supply the muscles directly involved in training, significant improvements in vascular function have been found. These improvements are more noticeable after active training than with a passive training regimen, such as passive static stretching. On the contrary, at the systemic level the effects of active or passive training are less clear and, above all, it is not evident whether there is a difference in the effects induced at the level of vascular function in arteries supplying muscles not directly involved in training. The aim of the study is to clarify the local and systemic effect of an active training protocol (single leg knee extension, SLKE) and of a passive training protocol (passive static stretching training, PST) applied to the lower limbs lasting 8 weeks on the local (femoral artery) and systemic (brachial artery) vascular function.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
Single (Outcomes Assessor)

盲法说明

Blind to intervention

入排标准

年龄范围
20 Years 至 30 Years(Adult)
性别
All
接受健康志愿者
是

入选标准

  • 未提供

排除标准

  • •neurological, vascular and musculoskeletal disorders of the lower and upper limbs;
  • •being on pharmacological therapy related to either neural and/or vascular response, including hormonal contraceptives and oral supplements;
  • •being a current or former smoker;
  • •having an irregular menstrual cycle (26 to 35 days) up to 3 months before the beginning of the study;
  • •contraindications to joint mobilization; regular involvement in a SLKE or PS training programme.

研究组 & 干预措施

Single leg knee extension training (SLKE)

Experimental

Active 8-week training involving lower limbs. SLKE participants will be involved in a 8-week aerobic training protocol involving the knee extensor muscles. The training will be held on an Anderson and Saltin ergometer, 3 times per week, with a single session duration of 33.3 min. Total weekly duration: 100 min.

干预措施: Training (Other)

Passive static stretching training (PST)

Active Comparator

Passive 8-week training involving lower limbs. PST participants will be involved in a 8-week passive static training training involving the knee extensor muscles. The training will have a frequency of 5 times per week, with a single duration of 20 min. Total weekly duration: 100 min

干预措施: Training (Other)

Control (CTRL)

No Intervention

CTRL will not receive any intervention.

结局指标

主要结局

Change from baseline in brachial artery flow mediated dilation

时间窗: Change from baseline in percentage flow mediated dilation at 8 weeks

Flow mediated dilation was performed at brachial artery level. An arterial pressure cuff was placed around the forearm immediately distal to the olecranon process to provide an ischemic stimulus when inflated. Following baseline assessment, the blood pressure cuff was inflated to 250 mmHg. Artery diameter was and blood flow were resumed at baseline, 30 s prior to cuff deflation and continued for 2 min post-deflation by a linear array transducer attached to a high-resolution ultrasound machine. When an optimal image was obtained, the probe was held stable and longitudinal in B-mode, acquiring images of the lumen-arterial wall interface. Continuous Doppler velocity assessments were also obtained and collected using the lowest possible insonation angle (\<60°). Data were exported and analyzed using commercially available software. Flow mediated dilation was quantified as the maximal change in artery diameter after cuff release, expressed as a percentage increase above baseline (%).

次要结局

  • Change from baseline in femoral artery delta blood flow(Change from baseline in Delta Blood Flow at 8 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Emilano Cè

Associate Professor

University of Milan

研究点 (1)

Loading locations...

相似试验