The Effect of High and Low Roasted Coffee on Vascular Response
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Vascular response measured by flow mediated dilatation (FMD)
研究概览
简要总结
Evidence suggests that a diet rich in plant phenolic compounds may induce beneficial vascular effects. Coffee is a good source of phenolic compounds called chlorogenic acids (CGA), however the level of CGA is reduced during the roasting process.
The aim of this study is to investigate the effect of coffee roasting on vascular response. The investigators hypothesize that coffee roasted to a lesser extent will exert a favourable vascular response over more heavily roasted coffee due to the higher levels of CGA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 19 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •A signed consent form
- •Age 19-35 years
- •Body mass index - 18.5-30 kg/m2
- •Normal blood pressure at screening (< 150/90)
排除标准
- •Blood pressure > 150/90 mmHg
- •Haemoglobin (anaemia marker) < 125 g/l
- •Gamma GT (liver enzymes) > 80 IU/l
- •Cholesterol > 6.5 mmol/l
- •Had suffered a myocardial infarction or stroke in the previous 12 months
- •Suffers from any reproductive disorder
- •Suffers from any blood-clotting disorder
- •Suffers from any metabolic disorders (e.g. diabetes or any other endocrine or liver diseases)
- •Any dietary restrictions or on a weight reducing diet
- •Drinking more than 21 units per week
- •On any lipid-modifying medication
- •On any blood pressure lowering medication
- •On any medication affecting blood clotting
- •Planning on altering consumption of vitamin supplements/fish oil capsules during the course of the study
- •Regular or vigorous exercise (3 times/week, 20 minutes each session)
- •Vegetarians or vegans
研究组 & 干预措施
High roast coffee
110mg caffeine with 108 mg chlorogenic acid at start of study
干预措施: Control (Caffeine dissolved in water) (Dietary Supplement)
Low roast coffee
110 mg caffeine with 235 mg chlorogenic acid at start of the study
干预措施: Low roast coffee (Dietary Supplement)
Control
110 mg caffeine at start of study
干预措施: High roast coffee (Dietary Supplement)
结局指标
主要结局
Vascular response measured by flow mediated dilatation (FMD)
时间窗: Change from baseline to 2 hours
次要结局
未报告次要终点
研究者
Jeremy Paul Edward Spencer
Professor
University of Reading