Effects of 6-week Resistance Training Intervention on Gut Microbiome and Cardiometabolic Outcomes in Adults With Overweight and Obesity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Change in stool microbiome diversity
研究概览
简要总结
The overall objective of this study is to investigate the effects of resistance training on the gut microbiome and cardiometabolic outcomes in adults with overweight and obesity.
详细描述
The overall objective of this study is to investigate the effects of resistance training on the gut microbiome and cardiometabolic outcomes in adults with overweight and obesity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-35 years
- •BMI: 25-45 kg/m2
- •Sedentary lifestyle
- •Consistent diet patterns
- •Weight-stable (<4 kg change over the last 3 mo)
- •Willingness to adhere to resistance training protocol and not change diet
- •Non-smoker >1 year or more
排除标准
- •Disabilities preventing adherence to resistance training protocol
- •Recent start of medications that affect metabolism or appetite
- •Antibiotics
- •Drug therapy for coronary artery disease, peripheral artery disease, congestive heart failure, or dyslipidemia
- •Uncontrolled hypertension and blood pressure ≥ 180/110
- •Gastrointestinal disease and/or bariatric surgery
- •Illicit drug use
- •Pregnant or lactating individuals
研究组 & 干预措施
Conventional physical activity guidelines
Participants are given recommendations on physical activity guidelines
干预措施: Conventional physical activity guidelines (Other)
Resistance training
Participants will undergo 6 weeks of supervised resistance training
干预措施: Resistance training (Behavioral)
结局指标
主要结局
Change in stool microbiome diversity
时间窗: Change over 6 weeks
16s rRNA sequencing
Change in stool microbiome composition
时间窗: Change over 6 weeks
16s rRNA sequencing
次要结局
- Change in fasting glucose(change over 6 weeks)
- Fat mass(Change over 6 weeks)
- Sleep Quality(change over 6 weeks)
- 24hr appetite ratings(Once at baseline and at the end of 6 week intervention)
- Change in Body mass(change over 6 weeks)
- Hip circumference(change over 6 weeks)
- Physical activity(change over 6 weeks)
- Change in blood pressure(change over 6 weeks)
- Fat free mass(Change over 6 weeks)
- Change in glucose regulation(change over 6 weeks)
- Sleep Duration(change over 6 weeks)
- Waist circumference(change over 6 weeks)
- Short chain fatty acids(Change over 6 weeks)
研究者
Jaapna Dhillon
Assistant Professor
University of Missouri-Columbia