Comparative efficacy of intralesional 5-Fluorouracil and intralesional MMR vaccine in verruca vulgaris
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- To compare the efficacy of intralesional 5-FU and intralesional MMR vaccine therapy in verruca vulgaris
研究概览
简要总结
Verruca vulgaris is a common dermatological condition. Current treatment options for verruca vulgaris include destructive, topical and immunological therapies. MMR vaccine has an immunomodulatory activity and has been postulated to have effect on injected as well as distant warts with almost no side effects except pain at injection site in patients of warts. 5-FU has a cytotoxic effect and when given intralesionally shows an early response to treatment, have high clearance rates and less recurrence rate. This study aims at making a comparison between the therapeutic efficacy of I/L 5-FU and I/L MMR vaccine as there are no head to-head studies in the literature comparing the efficacy of intralesional 5-FU and intralesional MMR vaccine in similar settings.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 14.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •All consecutive patients having lesions of verruca vulgaris.
- •Patients between the ages of 14-60 years.
排除标准
- •Pregnant or females planning for pregnancy or lactating mothers.
- •Immunocompromised individuals including HIV-AIDS.
- •Patients with known hypersensitivity to MMR vaccine or components of the vaccine (e.g. neomycin, gelatin) or 5-FU.
- •Patients having any significant systemic illness.
- •Patients having taken any vaccine in the last 4 weeks.
结局指标
主要结局
To compare the efficacy of intralesional 5-FU and intralesional MMR vaccine therapy in verruca vulgaris
时间窗: 0, 2, 4, 6, 8, 12 weeks
次要结局
- To assess the adverse effects of these therapies(0, 2, 4, 6, 8, 12 weeks)
研究者
Dr Aashali
Government Medical College and Hospital, Chandigarh