ApoB48IC2 Metabolism in Plasma and Interstitial Fluid
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- ApoB48 levels in blood and interstitial fluid
研究概览
简要总结
Postprandial increases in the levels of atherogenic chylomicron remnant lipoprotein particles have long been considered a presumable risk factor for the development of atherosclerosis with time, also in normolipidemic subjects. apoB-48 (Chylomicron) in blood is a specific marker for intestinal derived lipoproteins. Specific aim: To determine if apoB-48 containing lipoproteins may appear in IC in the postprandial state after a standard meal and investigate the effect fasting and feeding have on levels of lipids, apolipoproteins and the cholesterol component of lipoproteins in IF and plasma.
Methodology: Intercellular fluid will be collected using the cup technique. IF will be collected in intervals corresponding to different periods after food intake. The IF from these different occasions will then be analysed and compared using FPLC and Elisa.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Over 18 years.
- •For the T2D study group: Diagnosed with type 2 diabetes.
排除标准
- •For subjects with type 2 diabetes:
- •Systemic inflammatory disease that requires active treatment
- •Thyroid disease that requires active treatment
- •Skin disease that requires active treatment and causes significant changes in the area of the skin that is to be investigated
- •Treatment with oral glucocorticoids
- •Levels of SR, TSH, T4 or Hemoglobin in the blood pronouncedly outside the reference range
- •Pregnancy
- •For healthy controls:
- •Registered disease in the health declaration that requires continuous systemic treatment. Exception to the above: well controlled hypertension in which case the subject should not have treatment with more than one antihypertensive drug, the drug must not be an alpha-blocker or beta-blocker or thiazide diuretic
- •Skin disease that requires active treatment and causes significant changes in the area of the skin that is to be investigated
- •Blood pressure pronouncedly above 140/90
- •Blood test results pronouncedly outside the reference range
- •Pregnancy
结局指标
主要结局
ApoB48 levels in blood and interstitial fluid
时间窗: 7 hours
次要结局
未报告次要终点
研究者
Mats Rudling
Professor
Karolinska University Hospital