Behavioral Assessment of the Brain Response to Bioactive Food Components Using Electroretinography (Brain's Response to Chocolate)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Psychoactive Effects Questionnaire in response to oral stimuli
研究概览
简要总结
The purpose of this study is to test how the brain responds when individuals eat enjoyable foods such as chocolate. Eating certain foods can make one want to keep eating even when feeling full, caused by dopamine in the brain. The researchers believe this dopamine response can be measured by looking at the individual's eye.
详细描述
With obesity at an all-time high, understanding eating behavior beyond physical need is a priority. Food reinforcement is driven by central dopamine activity. However, objective measurement of brain dopamine-related behavioral events is hindered by the lack of non-invasive, accessible techniques that are amenable to testing in a "naturalistic" environment. The goal of this project is to develop a non-invasive, accessible methodology to measure dopaminergic responses to food in a natural setting. This research will use a novel, hand-held electroretinograph (ERG) that does not require eye dilation and uses a skin electrode to measure retinal dopamine activity. Previous work establishes that retinal dopamine activity can be used as a proxy for central dopamine function. The ability to assess both subjective behavioral variables and central dopaminergic responses simultaneously will provide an ideal approach for innovative studies of the control of eating behavior.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •body mass index 20-30 kg/m2
- •free of any major illness or disease
排除标准
- •food allergies
- •participation in a weight loss diet or exercise program
- •pregnancy
- •lactation
- •metabolic illness or disease (diabetes, renal failure, thyroid illness, hypertension)
- •eye illness or disease (narrow angle glaucoma, macular degeneration, retinal detachment, cataracts)
- •psychiatric, neurological or eating disorders (schizophrenia, depression, Parkinson's Disease, Huntington's Disease, cerebral palsy, stroke, epilepsy, anorexia nervosa or bulimia nervosa)
- •take prescription medications except for oral contraceptives or antihyperlipidemia agents
结局指标
主要结局
Psychoactive Effects Questionnaire in response to oral stimuli
时间窗: 30 minutes
The number of positive responses on the Psychoactive Effects Questionnaire will increase in response to increases in the sugar content of the chocolate
Retinal dopamine response to oral stimuli
时间窗: 30 minutes
Electroretinograph beta wave amplitude will increase in response to increases in the amount of sugar in the chocolate
次要结局
- Scores on the Binge Eating Scale will correlate with the retinal dopamine and Psychoactive Effect Questionnaire responses(30 minutes)