NCT03089749终止不适用
Characterization of Human Autoantibody Titers After Central Nervous System Insult
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 63
- 试验地点
- 1
- 主要终点
- Quantitate Autoantibodies
研究概览
简要总结
The aim of the study is to quantitate Central Nervous System (CNS) autoantibody development in human blood using ELISA after human brain injury, spinal cord injury, and intra-axial brain surgeries.
详细描述
Study Objectives:
We aim to:
- Quantitate CNS autoantibody development in human blood using ELISA after human brain injury, spinal cord injury, and intra-axial brain surgeries. We also aim to characterize the temporal course of this response.
- Characterize how CNS autoantibody levels correlate with specific injury patterns as well as radiographic and clinical measures of injury severity.
- Determine how intercurrent infection and a history of prior CNS insult affects the temporal course and magnitude of autoantibody production.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Have a severe traumatic brain injury
- •Have spinal cord injury ASIA grade A, B or C
- •Undergoing resection of intra-axial brain tumors
排除标准
- •Participant who is pregnant
结局指标
主要结局
Quantitate Autoantibodies
时间窗: 5 years
Quantitate CNS autoantibody development and temporal course in human blood using ELISA after human brain injury, spinal cord injury, and intra-axial brain surgeries.
次要结局
- Autoantibody Correlation(5 years)
- Autoantibody Production and History(5 years)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Validation of the Concept of the Autoantibodies Directed Against the Neuropeptides Involved in Food Intake Regulation on the Incidental Cases of Eating DisordersEating DisorderNCT03510533University Hospital, Rouen211
撤回
不适用
Identification of Autoantibodies and Autoantigens in the Cerebrospinal Fluid of Patients With Spinal Cord TraumaBone Marrow FailureTraumaNCT03249129University Hospital, Lille
Unknown
不适用
Interest Balance Auto-immune Population in Patients With Focal Epilepsy of Unknown Cause, Not Structural, Not Genetics, Newly DiagnosedEpilepsyNCT02885207University Hospital, Strasbourg, France200
Unknown
不适用
Sensitivity and Specificity of TSA-CBA for Autoantibodies Against Neural Antigen DeterminationNMO Spectrum DisorderNMDA-R EncephalitisDiagnostic Self EvaluationImmune System DiseasesNervous System DiseasesAutoimmune Diseases of the Nervous SystemAutoimmune DiseasesNCT05414890Beijing Tiantan Hospital2,500
Unknown
不适用
Autoantibodies on Spinal Cord InjurySpinal Cord InjuriesNCT02493543Hospital Nacional de Parapléjicos de Toledo110