Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Blood Loss During Surgery
研究概览
简要总结
The purpose of this study is to determine whether a brief course of SSKI (saturated solution of potassium iodide) administered preoperatively provides any benefit in the surgical management of patients undergoing thyroidectomy as definitive management of their Graves Disease.
详细描述
Historically Potassium Iodide was given to patients for 1 week prior to thyroidectomy. This common practice was used to decrease thyroid function and prevent thyroid storm during the thyroidectomy. However, in modern practice, nearly all patients presenting for surgical management have been made euthyroid through the use of medications such as propylthiouracil. Despite this potassium iodine continues to be administered with the presumption that it decreases the friability of the gland making surgery easier, with less blood loss.
The outcomes to be measured in this surgery are operative time, operative complications and blood loss.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients with a clinical diagnosis of Graves Disease
- •Patients who have selected surgical resection as treatment of their Graves Disease
- •Prior use of anti thyroid medication so that patient is clinically and biochemically euthyroid
排除标准
- •Patients deemed unfit for surgery by operating surgeon or anesthesist
- •Patients who are clinically hyperthyroid or have T3 or T4 levels 2X the upper limit of normal
研究组 & 干预措施
Potassium Iodide
8 drops of Potassium Iodide in a glass of water, by mouth, daily for 7 days prior to operation.
干预措施: Potassium Iodide (Drug)
结局指标
主要结局
Blood Loss During Surgery
时间窗: up to 162 minutes
Blood loss in milliliters during surgery.
次要结局
未报告次要终点