CTRI/2024/07/071375尚未招募2/3 期
Comparison of Sequential lateral postural maneuver and Sustained hyperinflation maneuver as lung recruitment strategy in critically ill cirrhotic patients on mechanical ventilation A Randomised controlled trial
Institute Of Liver And Biliary Sciences Vasnt KunjNew Delhi1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2024年8月5日最近更新:
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- :To compare the physiological effects of the two recruitment
研究概览
简要总结
The dynamic process of reopening previously collapsed lung units through an intended transitory increase in trans pulmonary pressure is referred to as recruitment. • Recruitment maneuvers are methods for increasing the oxygenation by maintaining and reopening non-aerated areas of the lungs. 7 • Useful in
- Improving gas exchange
- Improving respiratory compliance • Patients receiving positive pressure ventilation are prone to develop atelectasis and need periodic recruitment. • In cirrhotic patients on ventilator, following are the reasons for developing atelectasis. • Ascites that contributes to the loss of aeration in caudal and dependent lung segments leading to atelectasis and airway closure. • Thoracic compliance is decreased by respiratory anomalies including hepatic hydrothorax and pleural effusions (chest wall edema). • A relative immunocompromised status combined with an overactive inflammatory response increases the risk of pneumonia and acute lung damage.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)(—)
- 性别
- All
入选标准
- •All chronic liver disease patients and ACLF patients.
- •• Body mass index ≤ 35 kg/m2 • Hypoxemic patients with PaO2/FiO2 ratio measured by blood gas analysis of 150 to 200.
排除标准
- •• Pregnancy • COPD • Increased intracranial pressure.
- •• Unstable spine or pelvic fractures • Patients with Pacemaker and Automatic implantable cardio-defibrillator • Hemodynamic instability defined as persistent mean arterial pressure lower than 60 mm Hg despite adequate fluid resuscitation and two vasopressors or increase of vasopressor dose by 30% in the previous 6 hours.
- •• Patients with large pleural effusions and Intercoastal drains.
结局指标
主要结局
:To compare the physiological effects of the two recruitment
时间窗: 30 minutes
maneuvers on the oxygenation (PaO2/FiO2 ratio) after 30 minutes
时间窗: 30 minutes
次要结局
- To study the effect of recruitment maneuver on(▪ Pulmonary mechanics – Compliance, Peak airway pressure, plateau)
研究者
Dr Sahithi Latha Ronanki
Institute Of Liver And Biliary Sciences
研究点 (1)
Loading locations...
相似试验
尚未招募
不适用
Segmental Lung Recruitment: a Randomized Controlled TrialNCT07442708Clinical Hospital Center Rijeka20
已完成
不适用
Effect of Head and Neck Positioning on Lung Sliding in Healthy VolunteersNCT07351201Ankara Etlik City Hospital31
已完成
不适用
Effect of Recruitment Maneuver on Postoperative Atelectasis Assessed by Lung Ultrasound in Laparoscopic CholecystectomyPulmonary AtelectasisNCT07324122Fatih Sultan Mehmet Training and Research Hospital80
尚未招募
不适用
Perioperative Recovery Outcomes With a Spontaneous Breathing Strategy in Older Lung Transplant RecipientsNCT07384507The First Affiliated Hospital of Guangzhou Medical University60
招募中
Phase 3 4
Comparison of 110 degree rotation with 90 degree rotation for left double lumen tube placementCTRI/2024/12/078127AIIMS200
