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临床试验/CTRI/2024/07/071375
CTRI/2024/07/071375尚未招募2/3 期

Comparison of Sequential lateral postural maneuver and Sustained hyperinflation maneuver as lung recruitment strategy in critically ill cirrhotic patients on mechanical ventilation A Randomised controlled trial

Institute Of Liver And Biliary Sciences Vasnt KunjNew Delhi1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2024年8月5日最近更新:

试验速览

阶段
2/3 期
状态
尚未招募
发起方
入组人数
60
试验地点
1
主要终点
:To compare the physiological effects of the two recruitment

研究概览

简要总结

The dynamic process of reopening previously collapsed lung units through an intended transitory increase in trans pulmonary pressure is referred to as recruitment. • Recruitment maneuvers are methods for increasing the oxygenation by maintaining and reopening non-aerated areas of the lungs. 7 • Useful in

  1. Improving gas exchange
  2. Improving respiratory compliance • Patients receiving positive pressure ventilation are prone to develop atelectasis and need periodic recruitment. • In cirrhotic patients on ventilator, following are the reasons for developing atelectasis. • Ascites that contributes to the loss of aeration in caudal and dependent lung segments leading to atelectasis and airway closure. • Thoracic compliance is decreased by respiratory anomalies including hepatic hydrothorax and pleural effusions (chest wall edema). • A relative immunocompromised status combined with an overactive inflammatory response increases the risk of pneumonia and acute lung damage.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
None

入排标准

年龄范围
18.00 Year(s) 至 99.00 Year(s)(—)
性别
All

入选标准

  • All chronic liver disease patients and ACLF patients.
  • • Body mass index ≤ 35 kg/m2 • Hypoxemic patients with PaO2/FiO2 ratio measured by blood gas analysis of 150 to 200.

排除标准

  • • Pregnancy • COPD • Increased intracranial pressure.
  • • Unstable spine or pelvic fractures • Patients with Pacemaker and Automatic implantable cardio-defibrillator • Hemodynamic instability defined as persistent mean arterial pressure lower than 60 mm Hg despite adequate fluid resuscitation and two vasopressors or increase of vasopressor dose by 30% in the previous 6 hours.
  • • Patients with large pleural effusions and Intercoastal drains.

结局指标

主要结局

:To compare the physiological effects of the two recruitment

时间窗: 30 minutes

maneuvers on the oxygenation (PaO2/FiO2 ratio) after 30 minutes

时间窗: 30 minutes

次要结局

  • To study the effect of recruitment maneuver on(â–ª Pulmonary mechanics – Compliance, Peak airway pressure, plateau)

研究者

发起方
Institute Of Liver And Biliary Sciences Vasnt KunjNew Delhi
申办方类型
Research institution and hospital
责任方
Principal Investigator
主要研究者

Dr Sahithi Latha Ronanki

Institute Of Liver And Biliary Sciences

研究点 (1)

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