Daily Interruption of Sedation Versus Non Sedation in Mechanically Ventilated Respiratory Failure Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- duration of mechanical ventilation
研究概览
简要总结
Daily interruption of sedation is one of the modalities which is known to enhance early weaning and separation from mechanical ventilation . Daily sedation interruption is also known to help decreasing incidence of ventilator associated pneumonia. The new modality is no sedation.
详细描述
there is an increase of incidence of chronic obstructive lung disease associated respiratory failure which necessitates invasive mechanical ventilation. It is well known that one of the bundles for enhanced recovery of such cases is the daily interruption of sedation . Recently studies have demonstrated the feasibility of just using sedation for initiation of mechanical ventilation, then utilization of no sedation technique as a more this offers less side effects .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Obstructive lung disease
- •Respiratory failure
- •Invasive mechanical ventilation
排除标准
- •Neurological deficit
- •Cognitive dysfunction
- •Extensive malignancy
- •septic Shock
研究组 & 干预措施
Daily interruption of sedation
Daily interruption of sedation will be done at 7 am daily by stoppage of midazolam infusion
干预措施: Daily interruption of midazolam (Drug)
结局指标
主要结局
duration of mechanical ventilation
时间窗: first 30 days
number of days of mechanical ventilation
次要结局
未报告次要终点
研究者
Emad Zarief , MD
Clinical professor
Assiut University